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Başlık: Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in patients with type-1 diabetes mellitus
Yazarlar: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
0000-0002-4177-3478
0000-0002-3595-6286
0000-0002-7687-3284
Çinkılıç, Nilüfer
Kıyıcı, Sinem
Çelikler, Serap
Vatan, Özgür
Gül, Özen Öz
Tuncel, Ercan
Bilaloğlu, Rahmi
AAH-2767-2021
AAH-5296-2021
O-7508-2015
AAI-1005-2021
26533892300
12753880400
8234554800
16235098100
26040787100
7006929833
6505804122
Anahtar kelimeler: Type-1 diabetes
Chromosome aberrations
Sister chromatid exchange
Micronucleus formation
Oxidative dna-damage
Strand breakage
Cancer-risk
Comet assay
Stress
Cells
Instability
Induction
Biotechnology & applied microbiology
Genetics & heredity
Toxicology
Yayın Tarihi: 31-May-2009
Yayıncı: Elsevier
Atıf: Çinkılıç, N. vd. (2009). "Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in patients with type-1 diabetes mellitus". Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 676(1-2), 1-4
Özet: Oxidative stress-induced DNA damage seems to play a role in the pathogenesis of type-1 diabetes mellitus and its complications. Several in vitro assays have been used to measure the DNA damage produced by oxidative stress. In the present study, we aimed to investigate the frequency of sister chromatid exchange (SCE), chromosomal aberrations (CA) and micronuclei (MN) in type-1 diabetes mellitus patients compared with healthy controls. SCE. CA and MN tests were carried out with the blood-cell cultures from 35 type-1 diabetic patients and 15 healthy, age- and sex-matched control subjects. The mean age of the type-1 diabetic patients was 31.89 +/- 10.01 years, with a mean duration of the diabetes of 7.8 +/- 6.02 years. The mean level of HbA1c of the type-1 diabetic patients was 8.37 +/- 1.36%. Only three (8.5%) patients with type-1 diabetes mellitus had an HbA1c level below 7%. Patients with type-1 diabetes mellitus showed a higher frequency of SCE compared with controls (5.44 +/- 1.47 and 2.54 +/- 0.82, respectively, p < 0.001). but there was no significant correlation between the duration of diabetes, HbA1c and SCE. No significant difference was found in CA or MN frequency in type-1 diabetic patients compared with controls. In conclusion, these results suggest that type-1 diabetes mellitus is a condition with genomic instability characterized by an increased level of SCE. Hyperglycemia-induced oxidative stress may be the underlying factor of the increased SCE frequency.
URI: https://doi.org/10.1016/j.mrgentox.2009.02.014
https://www.sciencedirect.com/science/article/pii/S1383571809001284
http://hdl.handle.net/11452/22880
ISSN: 1383-5718
Koleksiyonlarda Görünür:Web of Science

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