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Başlık: Urinary IL-18: A marker of contrast-induced nephropathy following percutaneous coronary intervention?
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.
0000-0003-0463-6818
0000-0003-2467-9356
0000-0002-8974-8837
0000-0003-4518-5283
Gül, Cuma Bülent
Gullulu, Mustafa
Oral, Barboros
Aydınlar, Ali
Öz, Özen
Budak, Ferah
Ylmaz, Yusuf
Yurtkuran, Mustafa Abbas
K-7285-2012
F-4657-2014
F-4657-2014
F-4657-2014
23988796000
6602684544
7004498001
6603131517
15074213200
6701913697
22936014300
7003389525
Anahtar kelimeler: Medical laboratory technology
Biomarker
Contrast agent nephropathy
Interleukin-18
Urine
Acute kidney injury
Yayın Tarihi: May-2008
Yayıncı: Pergamon-Elsevier Science
Atıf: Gül, C. B. vd. (2008). ''Urinary IL-18: A marker of contrast-induced nephropathy following percutaneous coronary intervention?''. Clinical Biochemistry, 41(7-8), 544-547.
Özet: Objectives: Contrast-induced nephropathy (CIN) is a complication that is underestimated in clinical practice after cardiac catheterization. Recently, the value of interleukin (IL)-18 as a novel biomarker for the detection of acute renal failure has been highlighted. In the present study, we sought to investigate whether urine IL-18 may be an early diagnostic marker of CIN. Design and methods: We performed a nested case-control study using a hospital based cohort of all patients (n=157) admitted for elective PCI for stable angina to the Uludag University School of Medicine between February 2007 and June 2007. We identified 15 patients (9.5%) with CIN. Controls were matched with cases at an attempted 2.5:1 ratio by age and gender. Urinary IL-18 values were measured before as well as 24 and 72 It after the PCI. Results: No statistically significant differences in urine IL-18 were detected between cases (n=15) and controls (n=36) or between the patient samples obtained before PCI and after the invasive procedure in both study groups. Conclusions: These findings argue against the hypothesis that urine IL-18 may be clinically useful as a biomarker of CIN after radiological procedures requiring intravascular administration of iodinated contrast media. Further studies with larger sample sizes are needed to validate our findings.
URI: https://doi.org/10.1016/j.clinbiochem.2008.01.002
https://www.sciencedirect.com/science/article/pii/S0009912008000106
http://hdl.handle.net/11452/22928
ISSN: 0009-9120
1873-2933
Koleksiyonlarda Görünür:Web of Science

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