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Title: | Effects of pioglitazone and retinoic acid in a rotenone model of parkinson's disease |
Authors: | Ulusoy, Gökhan K. Çelik, Turgay Kayır, Hakan Işık, Ahmet T. Uzbay, Tayfun I. Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. Gürsoy, Murat 57197640824 |
Keywords: | Neurosciences & neurology Rotenone Parkinson's disease Pioglitazone Retinoic acid Rat(s) Gamma agonist pioglitazone Mptp model Alpha-synuclein Mouse model Degeneration Inhibition Exposure Receptor Neurons Neuroprotection |
Issue Date: | 15-Jul-2011 |
Publisher: | Pergamon-Elsevier Science |
Citation: | Ulusoy, G. K. vd. (2011). "Effects of pioglitazone and retinoic acid in a rotenone model of parkinson's disease". Brain Research Bulletin, 85(6), 380-384. |
Abstract: | Parkinson's disease (PD) is a late-onset, progressive and neurodegenerative disorder of unknown etiology. Besides the other therapeutic approaches, new drug options in pharmacotherapy of PD are important. The aim of the present study was to investigate the effects of pioglitazone and retinoic acid, antioxidant and neuroprotective agents, on rotenone-induced model of PD in rats. Adult male Wistar rats (260-373 g) were subjects. Rotenone (2.5 mg/kg, sc) was injected to rats for 70 days. At the end of rotenone administration, rats were treated with pioglitazone (10 mg/kg, ip) and retinoic acid (1 mg/kg, ip) or vehicles for 15 days. Then, rats were tested for evaluation of Parkinson signs by measurement of locomotor activity. In addition, dopamine levels were detected in striatum, hippocampus and hypothalamus in individual groups of control, rotenone and pioglitazone or retinoic acid-treated rats. Rotenone significantly reduced locomotor activity of the rats. It also significantly reduced dopamine levels in striatum and hippocampus, but not hypothalamus. Pioglitazone and retinoic acid reversed in reduction of locomotor activity significantly. Pioglitazone, but not retinoic acid, significantly reversed the reduced striatal dopamine level. Both drugs were ineffective on reduced levels of dopamine in hippocampus. Our results suggest that pioglitazone and retinoic acid have some beneficial effects on rotenone-induced model of PD in rats. Pioglitazone seems to be more effective than retinoic acid. These agents may be helpful for preventing or controlling of some signs of PD. |
URI: | https://doi.org/10.1016/j.brainresbull.2011.05.001 https://www.sciencedirect.com/science/article/pii/S0361923011001444 http://hdl.handle.net/11452/22930 |
ISSN: | 0361-9230 1873-2747 |
Appears in Collections: | Scopus Web of Science |
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