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Başlık: Long term dietary restriction ameliorates swimming exercise-induced oxidative stress in brain and lung of middle-aged rat
Yazarlar: Uludağ Üniversitesi/Eğitim Fakültesi/ Beden Eğitimi ve Spor Bölümü.
Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Bölümü.
0000-0003-0537-2113
0000-0003-0297-846X
Aydın, Cenk
Sonat, Füsun Ak
Kocamer, Şengül Şahin
Cangül, Taci
Özkaya, Güven
AAB-4360-2021
A-4421-2016
7005426982
26428428000
27867938700
6602486125
16316866500
Anahtar kelimeler: Antioxidants
Brain
Dietary restriction
Exercise
Oxidative stress
Caloric restriction
Lipid-peroxidation
Glutathione homeostasis
Food restriction
Liver
Supplementation
Generation
Markers
Damage
Dna
Life sciences & biomedicine - other topics
Animalia
Rattus
Yayın Tarihi: Oca-2009
Yayıncı: Natl Inst Science Communication-Niscair
Atıf: Aydın, C. vd. (2009). "Long term dietary restriction ameliorates swimming exercise-induced oxidative stress in brain and lung of middle-aged rat". Indian Journal of Experimental Biology, 47(1), 24-31.
Özet: Exhaustive exercise may generate oxidative stress in brain and reported findings are conflicting. Long term dietary restriction (DR) may be useful in the inhibiting of free oxygen radicals generated during exhaustive exercise in the brain of rat. Hence, in this study we evaluated beneficial effects of long term DR on the oxidative stress and antioxidant enzyme systems in brain cortex and lung in rats after different intensities of swimming exercise. Sprague-Dawley rats (60) were assigned as DR and ad libitum (AL) groups, and each group was further subdivided into three groups namely control (sedentery), submaximal exercise (endurance exercise) and maximal exercise (exhaustive swimming exercise) groups. Animals in the endurance exercise group swam 5 days/week for 8 weeks while exhaustive swimming group was subjected to an acute bout of exercise. With the increase in intensity of exercise, degree of lipid peroxidation (LP) and protein oxidation (PO) were also increased in DR and AL groups; however rate of increase was lower in DR group than AL group. Glutathione (GSH) and glutathione peroxidase (GSH-Px) activity were lower but glutathione reductase (GR) activity was higher in DR group compared to AL group in endurance and exhaustive swimming exercise. With increase in exercise intensity, GSH and GR enzyme activity decreased, whereas an increase was observed in GSH-Px enzyme activity. There was no difference in LP, PO, GSH and GR activity between DR and AL groups. GSH-Px activity in brain cortex was significantly lower in DR group than in AL group and sedentary rats. Results indicate that long term dietary restriction may protect against endurance and exhaustive swimming exercise-induced oxidative stress in rats by inhibiting oxidative stress.
URI: http://hdl.handle.net/11452/22931
ISSN: 0019-5189
Koleksiyonlarda Görünür:Scopus
Web of Science

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