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http://hdl.handle.net/11452/22949
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Türeyen, Kudret | - |
dc.date.accessioned | 2021-12-02T08:47:35Z | - |
dc.date.available | 2021-12-02T08:47:35Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | Şahin, S. vd. (2010). "Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats". Journal of Clinical Neuroscience, 17(2), 227-231. | en_US |
dc.identifier.issn | 0967-5868 | - |
dc.identifier.uri | https://doi.org/10.1016/j.jocn.2009.05.016 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0967586809003701 | - |
dc.identifier.uri | http://hdl.handle.net/11452/22949 | - |
dc.description.abstract | The effects of citicoline used either alone or in combination with hypothermia on the suppression of apoptotic processes after transient focal cerebral ischemia were investigated. Middle cerebral artery occlusion (MCAo) was performed for 2 hours on Sprague-Dawley (SD) rats using intraluminal thread insertion. The treatment groups were as follows: Group 1, sham-operate 1; Group 2, saline; Group 3, citicoline (400 mg/kg intraperitoneal.); Group 4, hypothermia (34 +/- 1 degrees C); Group 5, citicoline + hypothermia. All rats were reperfused for 24 hours, and after sacrifice and transcardiac perfusion, immunohistochemical (mean standard deviation, 0.71 +/- 0.75) was lower compared to Groups 3, 4 and 5 (2.33 +/- 0.81; 3.00 +/- 0.00; 2.20 +/- 0.83; p < 0.05). There was higher expression of cispase-3 proteins in Group 2 (2.28 +/- 0.95) compared to Group 5 (1.50 +/- 0.83; p < 0.05). Bax proteins were also increased in Group 2 (1.85 +/- 1.06) compared to Group 5 (0.40 +/- 0.54) and in Group 4 (2.00 +/- 0.00) compared to Group 5 (0.40 +/- 0.54; p < 0.05). Significant differences in caspase-9 immunostaining scores were found in Group 2 (2.29 +/- 0.96) compared to Group 5 (0.20 +/- 0.44) (p < 0.05); Group 3 (1.00 +/- 0.70) compared to Group 5 (0.20 +/- 0.44: p, < 0.05); and Group 4 (3.00 +/- 0.00; p < 0.05) compared to Group 5 (0.40 +/- 0.54; p < 0.05). Thus by suppressing apoptotic processes citicoline with hypothermia is more effective than ;either used alone in ameliorating cerebral damage after transient focal ischemia. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Cerebral ischemia | en_US |
dc.subject | Citicoline | en_US |
dc.subject | Hypothermia | en_US |
dc.subject | Rat | en_US |
dc.subject | Moderate therapeutic hypothermia | en_US |
dc.subject | Transient forebrain ischemia | en_US |
dc.subject | CDP-choline | en_US |
dc.subject | Artery occlusion | en_US |
dc.subject | Caspase activation | en_US |
dc.subject | Cell-death | en_US |
dc.subject | Brain | en_US |
dc.subject | Reperfusion | en_US |
dc.subject | Metabolism | en_US |
dc.subject | Pathway | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Apoptosis regulatory proteins | en_US |
dc.subject.mesh | Biological markers | en_US |
dc.subject.mesh | Brain | en_US |
dc.subject.mesh | Brain infarction | en_US |
dc.subject.mesh | Brain ischemia | en_US |
dc.subject.mesh | Combined modality therapy | en_US |
dc.subject.mesh | Cytidine diphosphate choline | en_US |
dc.subject.mesh | Disease models, animal | en_US |
dc.subject.mesh | Hypothermia, induced | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Infarction | en_US |
dc.subject.mesh | Middle cerebral artery | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Nerve degeneration | en_US |
dc.subject.mesh | Neurons | en_US |
dc.subject.mesh | Neuroprotective agents | en_US |
dc.subject.mesh | Nootropic agents | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Reperfusion injury | en_US |
dc.subject.mesh | Treatment outcome | en_US |
dc.title | Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats | en_US |
dc.type | Article | en_US |
dc.identifier.wos | 000274445900018 | tr_TR |
dc.identifier.scopus | 2-s2.0-73449126488 | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı. | tr_TR |
dc.identifier.startpage | 227 | tr_TR |
dc.identifier.endpage | 231 | tr_TR |
dc.identifier.volume | 17 | tr_TR |
dc.identifier.issue | 2 | tr_TR |
dc.relation.journal | Journal of Clinical Neuroscience | en_US |
dc.contributor.buuauthor | Şahin, Soner | - |
dc.contributor.buuauthor | Alkan, Tülin | - |
dc.contributor.buuauthor | Temel, Şehime Gülsün | - |
dc.contributor.buuauthor | Tolunay, Şahsine | - |
dc.contributor.buuauthor | Korfali, Ender | - |
dc.contributor.researcherid | AAH-2892-2021 | tr_TR |
dc.contributor.researcherid | AAH-1792-2021 | tr_TR |
dc.contributor.researcherid | AAG-8385-2021 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.identifier.pubmed | 20036128 | tr_TR |
dc.subject.wos | Clinical neurology | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.indexed.wos | SCIE | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.pubmed | Pubmed | en_US |
dc.wos.quartile | Q4 | en_US |
dc.contributor.scopusid | 8272141000 | tr_TR |
dc.contributor.scopusid | 6601953747 | tr_TR |
dc.contributor.scopusid | 6507885442 | tr_TR |
dc.contributor.scopusid | 6602604390 | tr_TR |
dc.contributor.scopusid | 7004641343 | tr_TR |
dc.subject.scopus | Citicoline; Neuroprotective Agents; Glycerylphosphorylcholine | en_US |
dc.subject.emtree | Caspase 3 | en_US |
dc.subject.emtree | Caspase 9 | en_US |
dc.subject.emtree | Citicoline | en_US |
dc.subject.emtree | Protein bax | en_US |
dc.subject.emtree | Protein bcl 2 | en_US |
dc.subject.emtree | Sodium chloride | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Apoptosis | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Brain damaged | en_US |
dc.subject.emtree | Brain protection | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Disease marker | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Heart perfusion | en_US |
dc.subject.emtree | Immunohistochemistry | en_US |
dc.subject.emtree | Induced hypothermia | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Middle cerebral artery occlusion | en_US |
dc.subject.emtree | Neuroprotection | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Sham procedure | en_US |
dc.subject.emtree | Suturing method | en_US |
dc.subject.emtree | Transient ischemic attack | en_US |
Appears in Collections: | Scopus Web of Science |
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