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Başlık: Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats
Yazarlar: Türeyen, Kudret
Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.
Şahin, Soner
Alkan, Tülin
Temel, Şehime Gülsün
Tolunay, Şahsine
Korfali, Ender
AAH-2892-2021
AAH-1792-2021
AAG-8385-2021
8272141000
6601953747
6507885442
6602604390
7004641343
Anahtar kelimeler: Apoptosis
Cerebral ischemia
Citicoline
Hypothermia
Rat
Moderate therapeutic hypothermia
Transient forebrain ischemia
CDP-choline
Artery occlusion
Caspase activation
Cell-death
Brain
Reperfusion
Metabolism
Pathway
Neurosciences & neurology
Yayın Tarihi: Şub-2010
Yayıncı: Elsevier
Atıf: Şahin, S. vd. (2010). "Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats". Journal of Clinical Neuroscience, 17(2), 227-231.
Özet: The effects of citicoline used either alone or in combination with hypothermia on the suppression of apoptotic processes after transient focal cerebral ischemia were investigated. Middle cerebral artery occlusion (MCAo) was performed for 2 hours on Sprague-Dawley (SD) rats using intraluminal thread insertion. The treatment groups were as follows: Group 1, sham-operate 1; Group 2, saline; Group 3, citicoline (400 mg/kg intraperitoneal.); Group 4, hypothermia (34 +/- 1 degrees C); Group 5, citicoline + hypothermia. All rats were reperfused for 24 hours, and after sacrifice and transcardiac perfusion, immunohistochemical (mean standard deviation, 0.71 +/- 0.75) was lower compared to Groups 3, 4 and 5 (2.33 +/- 0.81; 3.00 +/- 0.00; 2.20 +/- 0.83; p < 0.05). There was higher expression of cispase-3 proteins in Group 2 (2.28 +/- 0.95) compared to Group 5 (1.50 +/- 0.83; p < 0.05). Bax proteins were also increased in Group 2 (1.85 +/- 1.06) compared to Group 5 (0.40 +/- 0.54) and in Group 4 (2.00 +/- 0.00) compared to Group 5 (0.40 +/- 0.54; p < 0.05). Significant differences in caspase-9 immunostaining scores were found in Group 2 (2.29 +/- 0.96) compared to Group 5 (0.20 +/- 0.44) (p < 0.05); Group 3 (1.00 +/- 0.70) compared to Group 5 (0.20 +/- 0.44: p, < 0.05); and Group 4 (3.00 +/- 0.00; p < 0.05) compared to Group 5 (0.40 +/- 0.54; p < 0.05). Thus by suppressing apoptotic processes citicoline with hypothermia is more effective than ;either used alone in ameliorating cerebral damage after transient focal ischemia.
URI: https://doi.org/10.1016/j.jocn.2009.05.016
https://www.sciencedirect.com/science/article/pii/S0967586809003701
http://hdl.handle.net/11452/22949
ISSN: 0967-5868
Koleksiyonlarda Görünür:Scopus
Web of Science

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