Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/22973
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dc.date.accessioned2021-12-03T06:38:15Z-
dc.date.available2021-12-03T06:38:15Z-
dc.date.issued2009-09-
dc.identifier.citationİlçöl, Y. Ö. vd. (2009). "Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors". Shock, 32(3), 286-294.en_US
dc.identifier.issn1073-2322-
dc.identifier.urihttps://doi.org/10.1097/SHK.0b013e3181971b02-
dc.identifier.urihttps://journals.lww.com/shockjournal/Fulltext/2009/09000/CHOLINE_OR_CDP_CHOLINE_ALTERS_SERUM_LIPID.10.aspx-
dc.identifier.urihttp://hdl.handle.net/11452/22973-
dc.description.abstractWe showed previously that choline administration protects dogs from endotoxin-induced multiple organ injury and platelet dysfunctions. Because sepsis/endotoxemia is associated with alterations in lipid metabolism, we have investigated whether choline or cytidine-5'-diphosphate choline, a choline donor, alters serum lipid responses to endotoxin in dogs and rats. In response to endotoxin, serum concentrations of triglycerides, choline-containing phospholipids, total cholesterol, and high-density lipoprotein cholesterol increased in a dose- and time-related manner. Administration of choline (20 mg/kg i.v. in dogs or 90 mg/kg i.p. in rats) or cytidine-5'-diphosphate choline (70 mg/kg i.v. in dogs) 5 min before and 4 and 8 h after endotoxin blocked or attenuated the increases in serum triglycerides, total cholesterol, and nonesterified fatty acids. Endotoxin-induced elevations in serum phospholipid levels did not change in rats and were enhanced in dogs by choline. In rats, serum lipid response to endotoxin was accompanied by severalfold elevations in serum levels of hepatorenal injury markers; their elevations were also blocked by choline. Pretreatment with hexamethonium blocked choline's effects on serum lipids and hepatorenal injury markers. Pretreatment with atropine blocked endotoxin-induced elevations in serum lipid and hepatorenal injury markers, but failed to alter choline's actions on these parameters. Choline treatment improved survival rate of rats in lethal endotoxin shock. In conclusion, these data show that choline treatment alters serum lipid responses to endotoxin and prevents hepatorenal injury during endotoxemia through a nicotinic acetylcholine receptor-mediated mechanism. Hence, choline and choline-containing compounds may have a therapeutic potential in the treatment of endotoxemia/sepsis.en_US
dc.description.sponsorshipTurkish Academy of Sciences European Commission (TUBA)en_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCDP-cholineen_US
dc.subjectCholineen_US
dc.subjectDogen_US
dc.subjectEndotoxinen_US
dc.subjectHypertriglyceridemiaen_US
dc.subjectLPSen_US
dc.subjectRaten_US
dc.subjectSerum lipidsen_US
dc.subjectSerum phospholipidsen_US
dc.subjectTumor-necrosis-factoren_US
dc.subjectIncreasesen_US
dc.subjectLipoproteinsen_US
dc.subjectMetabolitesen_US
dc.subjectReleaseen_US
dc.subjectHypertriglyceridemiaen_US
dc.subjectAugmentsen_US
dc.subjectInsulinen_US
dc.subjectSystemen_US
dc.subjectShocken_US
dc.subjectGeneral & internal medicineen_US
dc.subjectHematologyen_US
dc.subjectSurgeryen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropineen_US
dc.subject.meshCholesterolen_US
dc.subject.meshCholineen_US
dc.subject.meshCytidine diphosphate cholineen_US
dc.subject.meshDogsen_US
dc.subject.meshEndotoxinsen_US
dc.subject.meshFatty acids, nonesterifieden_US
dc.subject.meshFemaleen_US
dc.subject.meshHexamethoniumen_US
dc.subject.meshKidneyen_US
dc.subject.meshLipid metabolismen_US
dc.subject.meshLipidsen_US
dc.subject.meshLiveren_US
dc.subject.meshMaleen_US
dc.subject.meshNicotinic antagonistsen_US
dc.subject.meshPhospholipidsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReceptors, nicotinicen_US
dc.subject.meshShock, septicen_US
dc.subject.meshTriglyceridesen_US
dc.titleCholine or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptorsen_US
dc.typeArticleen_US
dc.identifier.wos000269226000010tr_TR
dc.identifier.scopus2-s2.0-69549096230tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.relation.bapV-2003/86tr_TR
dc.contributor.orcid0000-0003-2918-5064tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.identifier.startpage286tr_TR
dc.identifier.endpage294tr_TR
dc.identifier.volume32tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalShocken_US
dc.contributor.buuauthorİlçöl, Yeşim Özarda-
dc.contributor.buuauthorYılmaz, Zeki-
dc.contributor.buuauthorCansev, Mehmet-
dc.contributor.buuauthorUlus, İsmail Hakkı-
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridM-9071-2019tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.identifier.pubmed19060783tr_TR
dc.subject.wosCritical care medicineen_US
dc.subject.wosHematologyen_US
dc.subject.wosSurgeryen_US
dc.subject.wosPeripheral vascular diseaseen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubmeden_US
dc.wos.quartileQ2en_US
dc.wos.quartileQ1 (Surgery)en_US
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.contributor.scopusid8872816100tr_TR
dc.contributor.scopusid7004271086tr_TR
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.emtreeAtropineen_US
dc.subject.emtreeCholineen_US
dc.subject.emtreeCiticolineen_US
dc.subject.emtreeEndotoxinen_US
dc.subject.emtreeFatty acid derivativeen_US
dc.subject.emtreeHexamethoniumen_US
dc.subject.emtreeLow density lipoprotein cholesterolen_US
dc.subject.emtreeNicotinic receptoren_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeEndotoxemiaen_US
dc.subject.emtreeExperimental dogen_US
dc.subject.emtreeKidney injuryen_US
dc.subject.emtreeLipid metabolismen_US
dc.subject.emtreeLiver injuryen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSeptic shocken_US
dc.subject.emtreeSurvival rateen_US
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