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Başlık: Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Veterinerlik Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.
0000-0003-2918-5064
0000-0001-9836-0749
İlçöl, Yeşim Özarda
Yılmaz, Zeki
Cansev, Mehmet
Ulus, İsmail Hakkı
D-5340-2015
M-9071-2019
AAL-8873-2021
35741320500
35944810500
8872816100
7004271086
Anahtar kelimeler: CDP-choline
Choline
Dog
Endotoxin
Hypertriglyceridemia
LPS
Rat
Serum lipids
Serum phospholipids
Tumor-necrosis-factor
Increases
Lipoproteins
Metabolites
Release
Hypertriglyceridemia
Augments
Insulin
System
Shock
General & internal medicine
Hematology
Surgery
Cardiovascular system & cardiology
Yayın Tarihi: Eyl-2009
Yayıncı: Lippincott Williams & Wilkins
Atıf: İlçöl, Y. Ö. vd. (2009). "Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors". Shock, 32(3), 286-294.
Özet: We showed previously that choline administration protects dogs from endotoxin-induced multiple organ injury and platelet dysfunctions. Because sepsis/endotoxemia is associated with alterations in lipid metabolism, we have investigated whether choline or cytidine-5'-diphosphate choline, a choline donor, alters serum lipid responses to endotoxin in dogs and rats. In response to endotoxin, serum concentrations of triglycerides, choline-containing phospholipids, total cholesterol, and high-density lipoprotein cholesterol increased in a dose- and time-related manner. Administration of choline (20 mg/kg i.v. in dogs or 90 mg/kg i.p. in rats) or cytidine-5'-diphosphate choline (70 mg/kg i.v. in dogs) 5 min before and 4 and 8 h after endotoxin blocked or attenuated the increases in serum triglycerides, total cholesterol, and nonesterified fatty acids. Endotoxin-induced elevations in serum phospholipid levels did not change in rats and were enhanced in dogs by choline. In rats, serum lipid response to endotoxin was accompanied by severalfold elevations in serum levels of hepatorenal injury markers; their elevations were also blocked by choline. Pretreatment with hexamethonium blocked choline's effects on serum lipids and hepatorenal injury markers. Pretreatment with atropine blocked endotoxin-induced elevations in serum lipid and hepatorenal injury markers, but failed to alter choline's actions on these parameters. Choline treatment improved survival rate of rats in lethal endotoxin shock. In conclusion, these data show that choline treatment alters serum lipid responses to endotoxin and prevents hepatorenal injury during endotoxemia through a nicotinic acetylcholine receptor-mediated mechanism. Hence, choline and choline-containing compounds may have a therapeutic potential in the treatment of endotoxemia/sepsis.
URI: https://doi.org/10.1097/SHK.0b013e3181971b02
https://journals.lww.com/shockjournal/Fulltext/2009/09000/CHOLINE_OR_CDP_CHOLINE_ALTERS_SERUM_LIPID.10.aspx
http://hdl.handle.net/11452/22973
ISSN: 1073-2322
Koleksiyonlarda Görünür:Scopus
Web of Science

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