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Başlık: Baseline and salt-stimulated paraoxonase and arylesterase activities in patients with chronic liver disease: Relation to disease severity
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.
0000-0003-4518-5283
0000-0002-3208-6211
0000-0003-4526-4352
Keskin, Murat
Dolar, Engin
Dirican, Melahat
Kıyıcı, Murat
Yılmaz, Yusuf
Gürel, Selim
Nak, Selim Giray
Gülten, Macit
Erdinç, Selda
AAI-4213-2021
AAG-9177-2021
AAG-6985-2021
23050640000
6602075084
6601919847
6507627491
22936014300
7003706434
6603336505
6603629209
24334883200
Anahtar kelimeler: Arylesterase
Chronic liver disease
Cirrhosis
Liver function tests
Paraoxonase
Uremic patients
Serum
Polymorphism
Cirrhosis
Damage
General & internal medicine
Yayın Tarihi: Nis-2009
Yayıncı: Wiley
Atıf: Keskin, M. vd. (2009). "Baseline and salt-stimulated paraoxonase and arylesterase activities in patients with chronic liver disease: Relation to disease severity". Internal Medicine Journal, 39(4), 243-248.
Özet: Background: It has been recently reported that serum paraoxonase (PON1) and arylesterase (ARE) activities may be significantly reduced in patients with chronic liver disease. The aim of the study was to investigate the relations between serum PON1 and ARE activities and the degree of liver damage in patients with chronic liver injury. Methods: We studied a total of 75 patients with chronic liver disease (50 patients with cirrhosis and 25 patients with chronic hepatitis) and 25 healthy comparison subjects. Baseline and salt-stimulated PON1 and ARE activities were determined in all study participants. Results: Baseline and stimulated PON1 and ARE activities were significantly lower in patients with chronic liver disease than in controls. Cirrhotic patients in Child-Pugh classes B and C subgroups had significantly reduced PON1 and ARE activities compared with Child-Pugh class A patients (both P-values < 0.01). Receiver operating characteristic curve analysis showed that serum ARE activity was the most effic Conclusion: Baseline and stimulated PON1 and ARE activities are reduced in patients with chronic liver disease. Serum ARE activity could be a suitable biomarker for the evaluation of the presence and severity of chronic liver damage.
URI: https://doi.org/10.1111/j.1445-5994.2009.01793.x
https://onlinelibrary.wiley.com/doi/10.1111/j.1445-5994.2009.01793.x
http://hdl.handle.net/11452/23000
ISSN: 1444-0903
1445-5994
Koleksiyonlarda Görünür:Scopus
Web of Science

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