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Başlık: Antipyretic effect of ketoprofen
Yazarlar: Aygün, Denizmen A.
Arısoy, Emin Sami
Seringeç, Murat
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Çelebi, Solmaz
Hacımustafaoğlu, Mustafa Kemal
Karalı, Yasin
Akgöz, Semra
Kurt, Ayşegül Neşe Çıtak
7006095295
49863694000
6602154166
14061863400
36152868000
Anahtar kelimeler: Acetaminophen
Children
Fever
Ibuprofen
Ketoprofen
Pharmacokinetics
Children
Blind
Pediatrics
Yayın Tarihi: Mar-2009
Yayıncı: Springer India
Atıf: Çelebi, S. vd. (2009). "Antipyretic effect of ketoprofen". Indian Journal of Pediatrics, 76(3), 287-291.
Özet: Objective. To investigate the efficacy and side effect of ketoprofen as well as compliance with respect to the taste of the drug and compare these parameters with those of acetaminophen and ibuprofen. Methods. A total of 301 patients between 1-14 years of age who attended to emergency rooms of three medical centers with the complaint of fever that required antipyretic therapy were included in the study. Fever was measured with the aid of a tympanic thermometer (Braun Kronberg 6014) and followed for 4-6 hours. The measurement was repeated at 30, 60, 120 minutes, and again 4-6 hours after the initial assessment. Results. The mean age of the patients was 47.8 +/- 41.1 months. The patients randomly received 15 mg/kg/dose of acetaminophen (n=112 group 1), 0.5 mg/kg/dose of ketoprofen (n=105, group 2), or 10 mg/kg/dose of ibuprofen (n=84, group 3). Temperature records in three groups was 38.4 +/- 0.7 degrees C, 38.4 +/- 0.7 degrees C, and 38.5 +/- 0.5 degrees C at 30 minutes; 38.0 +/- 0.7 degrees C, 37.9 +/- 0.7 degrees C, and 38.0 +/- 0.6 degrees C at 60 minutes (p > 0.05), 37.7 +/- 0.6 degrees C, 37.6 +/- 0.7 degrees C, and 37.7 +/- 0.5 degrees C at 120 minutes (p > 0.05); 37.5 +/- 0.7 degrees C, 37.3 +/- 0.6 degrees C, and 37.4 +/- 0.6 degrees C at 4-6 hours after admission (P > 0.05) respectively. The fever was significantly lower at 30, 60, and 120 minutes in all groups (p < 0.05) respectively. Early vomiting after medication (< 6 hours) was observed in 3.8%, 13.5%, and 9.6% respectively whereas late vomiting (6-48 hours) occurred in 1.3%, 2.7%, and 5.8% respectively (p > 0.05). Bad taste was expressed by 5.1%, 12.2%, and 5.8% early (< 6 hours), and 3.9%, 8.1%, and 3.8% late (6-48 hours) (p > 0.05). There were no differences between age groups for antipyretic effect, taste and adverse effect in three drugs (p > 0.05). Conclusion. All three drugs were similar in terms of efficacy, adverse effects, and compliance within 48 hours of therapy. These results suggest that ketoprofen may be used for antipyresis as an alternative to acetaminophen and ibuprofen.
URI: https://doi.org/10.1007/s12098-008-0234-z
https://link.springer.com/article/10.1007%2Fs12098-008-0234-z
http://hdl.handle.net/11452/23005
ISSN: 0019-5456
Koleksiyonlarda Görünür:Scopus
Web of Science

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