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Başlık: Obstructive sleep apnea causes oxidative damage to plasma lipids and proteins and decreases adiponectin levels
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
0000-0002-9027-1132
0000-0001-7377-9682
Vatansever, Ebru
Sürmen, Esma Gür
Ursavaş, Ahmet
Karadağ, Mehmet
AAG-8744-2021
AAI-3169-2021
AAG-7327-2021
16070622700
7801407302
8329319900
6601970351
Anahtar kelimeler: Neurosciences & neurology
Respiratory system
Sleep apnea
Oxidative stress
Protein oxidation
Adiponectin
Insulin-resistance
Endothelial function
Heart health
Risk-factors
Stress
Disease
Glucose
Peroxidation
Sensitivity
Disorders
Yayın Tarihi: Eyl-2011
Yayıncı: Springer Heidelberg
Atıf: Vatansever, E. vd. (2011). "Obstructive sleep apnea causes oxidative damage to plasma lipids and proteins and decreases adiponectin levels". Sleep and Breathing, 15(3), 275-282.
Özet: Obstructive sleep apnea (OSA) is associated with various metabolic disorders, and oxidative stress was suggested to play an important role. In the present study, we aimed to investigate serum adiponectin and oxidative stress markers, especially protein carbonyls, and to evaluate the correlation between these parameters and lipid, insulin and fasting glucose concentrations in OSA patients and controls. Blood was drawn from healthy male volunteers following full-night polysomnographic evaluation. Subjects were classified as controls (n = 24), mild OSA group (n = 9) and moderate-severe OSA group (n = 17) according to their apnea-hypopnea indices (AHIs). Serum lipids, fasting glucose, adiponectin, malondialdehyde (MDA), protein carbonyl concentrations, and paraoxonase activities were measured in all subjects. Results of this study indicated that serum adiponectin concentrations were significantly decreased and MDA and protein carbonyl concentrations were significantly elevated in OSA patients compared to the controls. Protein carbonyl and MDA concentrations were significantly and positively correlated with AHI, while a significant negative correlation was found between adiponectin concentrations and AHI. Adiponectin levels were negatively correlated with MDA levels. Results of this study, which is the first human study investigating and describing serum protein carbonyl concentrations in OSA patients, reveal that OSA causes increments in oxidative damage and decreases adiponectin levels. The recurrent hypoxia-reoxygenation attacks in OSA patients may activate oxidative stress, elevating sympathetic activity and leading to low levels of adiponectin.
URI: https://doi.org/10.1007/s11325-010-0378-8
https://link.springer.com/article/10.1007/s11325-010-0378-8
http://hdl.handle.net/11452/23233
ISSN: 1520-9512
Koleksiyonlarda Görünür:Scopus
Web of Science

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