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http://hdl.handle.net/11452/23336
Başlık: | Nasal pepsin assay and ph monitoring in chronic rhinosinusitis |
Yazarlar: | Özmen, Suay Yücel, Ömer Taşkın Sinici, İncilay Öğretmenoğlu, Oğuz Önerci, Metin Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı. 0000-0002-9698-0546 Özmen, Ömer Afşin A-1452-2019 55407733900 |
Anahtar kelimeler: | Research & experimental medicine Otorhinolaryngology Chronic rhinosinusitis Nasal lavage Pepsin assay Reflux disease gerd Gastroesophageal-reflux Laryngopharyngeal reflux Chronic sinusitis Gastric reflux Acid Manifestations Pathogenesis Disorders Laryngeal |
Yayın Tarihi: | May-2008 |
Yayıncı: | Willey |
Atıf: | Özmen, S. vd. (2008). ''Nasal pepsin assay and ph monitoring in chronic rhinosinusitis''. Laryngoscope, 118(5), 890-894. |
Özet: | Objectives/Hypothesis: The primary objective of this study was to determine the relationship between chronic rhinosinusitis (CRS) and laryngopharyngeal reflux (LPR). We also investigated the diagnostic value of pepsin in nasal lavage by means of fluorometric assay as compared with 24-hour dual-probe pH monitoring. Study Design and Methods: This is a controlled, prospective study from a retrospective dataset of 33 patients recruited for endoscopic sinus surgery between 2005 and 2006 in a tertiary care referral center (Hacettepe University Medical Center). All patients underwent 24-hour dual-probe pH monitoring and nasal lavage fluid investigation for pepsin. A fluorometric pepsin assay using casein-fluorescein isothiocyanate in nasal lavage fluid was used to detect LPR. The control group included 20 patients who were proven not to have sinusitis. Results: A higher incidence of pharyngeal acid reflux events was found in patients with CRS (29 of 33, 88%) compared with the control patients (11 of 20, 55%). The difference was statistically significant (P = .01). The fluorometric pepsin assay was correlated. to the results of 24-hour dual-probe monitoring for LPR diagnosis with a 100% sensitivity and 92.5% specificity. These data suggest that an association between CRS and LPR is present and that the detection of pepsin in nasal lavage fluid may provide a noninvasive and feasible method of LPR screening. |
URI: | https://doi.org/10.1097/MLG.0b013e318165e324 https://onlinelibrary.wiley.com/doi/full/10.1097/MLG.0b013e318165e324 http://hdl.handle.net/11452/23336 |
ISSN: | 0023-852X 1531-4995 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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