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http://hdl.handle.net/11452/23408
Başlık: | Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. 0000-0001-6466-5042 Alkan, Tülin AAH-1792-2021 6601953747 |
Anahtar kelimeler: | Neuronal protection Postconditioning Preconditioning Focal cerebral-ischemia Spreading depression Nitric-oxide Protein-synthesis Neuronal damage Rapid tolerance Cytochrome-c Injury Stroke Hypothermia Neurosciences & neurology Surgery |
Yayın Tarihi: | Eki-2009 |
Yayıncı: | Türk Nöroşirürji Derneği |
Atıf: | Alkan, T. (2009). "Neuroproctective effects of ischemic tolerance (preconditioning) and postconditioning". Turkish Neurosurgery, 19(4), 406-412. |
Özet: | Elucidation of the endogenous cell survival pathways involved in ischemic tolerance (preconditioning) and postconditioning has significant clinical implications for preventing neuronal damage in susceptible patients. Ischemic tolerance is a phenomenon in which the brain protects itself against future injury by adapting to low doses of noxious insults. Ischemic postconditioning is defined as brief periods of reperfusion alternating with re-occlusion applied during the very early minutes of reperfusion that mechanically alters the hydrodynamics of reperfusion. Similar pathways and molecules play a role in pre-and postconditioning but their roles and timing are different in each conditioning. Understanding the neuroprotective effects of mechanisms underlying conditionings has been elusive, but NNMA receptor activation, nitric oxide, inflammatory cytokines, and suppression of the innate immune system appear to have a role. Reactive oxygen species and classical ligand stimuli play a role in postconditioning with KATP channels and protein kinase C pathways acting as mediators. |
URI: | http://hdl.handle.net/11452/23408 |
ISSN: | 1019-5149 |
Koleksiyonlarda Görünür: | Scopus TrDizin Web of Science |
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