Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/23409
Title: Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
Authors: Kaya, Hakan
Desdicioğlu, Raziye
Sezik, Mekin
Özkaya, Okan
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Ulukaya, Engin
Yımaztepe, Arzu
Demirci, Meral
K-5792-2018
6602927353
8606136100
18534643800
Keywords: Oocyte apoptosis
Activation
Survival
Chemotherapy
Follicles
Granulosa
Caspase-3
Acid
Obstetrics & gynecology
Reproductive biology
Issue Date: Mar-2008
Publisher: Elsevier
Citation: Kaya, H. vd. (2008). ''Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?''. Fertility and Sterility, 89(3), 732-735.
Abstract: The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
URI: https://doi.org/10.1016/j.fertnstert.2007.03.065
https://www.sciencedirect.com/science/article/abs/pii/S0015028207007947
http://hdl.handle.net/11452/23409
ISSN: 0015-0282
1556-5653
Appears in Collections:Scopus
Web of Science

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