Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

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Başlık:	Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
Yazarlar:	Kaya, Hakan Desdicioğlu, Raziye Sezik, Mekin Özkaya, Okan Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. Ulukaya, Engin Yımaztepe, Arzu Demirci, Meral K-5792-2018 6602927353 8606136100 18534643800
Anahtar kelimeler:	Oocyte apoptosis Activation Survival Chemotherapy Follicles Granulosa Caspase-3 Acid Obstetrics & gynecology Reproductive biology
Yayın Tarihi:	Mar-2008
Yayıncı:	Elsevier
Atıf:	Kaya, H. vd. (2008). ''Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?''. Fertility and Sterility, 89(3), 732-735.
Özet:	The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
URI:	https://doi.org/10.1016/j.fertnstert.2007.03.065 https://www.sciencedirect.com/science/article/abs/pii/S0015028207007947 http://hdl.handle.net/11452/23409
ISSN:	0015-0282 1556-5653
Koleksiyonlarda Görünür:	Scopus Web of Science

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