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Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/23764
Başlık: A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
Topal, Ersun
Öztürk, Ersin
Şen, Gürol
Yerci, Ömer
Yılmazlar, Tuncay
16069863000
35070171400
23013375200
6603810549
6701800362
Anahtar kelimeler: Tissue plasminogen activator
Fondaparinux sodium
Adhesions
Peritoneum
Molecular-weight heparin
Plasminogen-activator
Surgery
Obstruction
Trauma
Surgery
Yayın Tarihi: Şub-2010
Yayıncı: Taylor & Francis
Atıf: Topal, E. vd. (2010). "A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions". Acta Chirurgica Belgica, 110(1), 71-75.
Özet: Purpose : Three different drugs affecting the coagulation process at various stages were studied for their effectiveness in preventing intra-peritoneal adhesion formation in rats. Material and Methods: Forty female Wistar-Albino rats divided into four groups based on the drugs administered during the experimental laparotomy and caecal abrasion : the control group - no drug administered, the intra-peritoneal tissue plasminogen activator (TPA) group, the subcutaneous fondaparinux sodium (FS) group and the intra-peritoneal activated drotrecogin alfa (ADA) group. After two weeks, intra-peritoneal adhesions were macroscopically and micro-scopically scored. Results : The macroscopic scores of the three groups were similar but all lower than the control group (p = 0.002). Inflammation (p = 0.023) and fibrosis (p = 0.019) scores were lower in just the ADA group when compared to the control group. Conclusions : All three agents were effective in preventing adhesions when compared to the control group. Nevertheless, ADA seemed the most effective except when considering clinical applicability, in which case FS seemed to offer the greatest advantage.
URI: https://doi.org/10.1080/00015458.2010.11680569
https://pubmed.ncbi.nlm.nih.gov/20306914/
http://hdl.handle.net/11452/23764
ISSN: 0001-5458
Koleksiyonlarda Görünür:Scopus
Web of Science

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