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http://hdl.handle.net/11452/23804
Başlık: | Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
Yazarlar: | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. 0000-0002-2593-7196 0000-0002-4177-3478 0000-0001-6225-774X Taş, Sibel Çelikler, Serap Ziyanok, Sedef Ayvalık Sarandöl, Emre Dirican, Melahat ABE-6873-2020 ABE-1716-2020 AAG-6985-2021 AAH-2767-2021 7004343411 8234554800 15128398000 55943324800 6601919847 |
Anahtar kelimeler: | Biochemistry & molecular biology Cell biology Ulva rigida Diabetes Oxidative stress Antioxidant status Hyperlipidemia Serum paraoxonase activity Vanadyl sulfate Mellitus Antioxidant Extract Mice Atherosclerosis Aminoguanidine Hyperglycemia Complications Chlorophyta Rattus Rattus norvegicus Ulva rigida |
Yayın Tarihi: | Mar-2011 |
Yayıncı: | Wiley |
Atıf: | Taş, S. vd. (2011). "Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats". Cell Biochemistry and Function, 29(2), 108-113. |
Özet: | This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus. |
URI: | https://doi.org/10.1002/cbf.1729 https://pubmed.ncbi.nlm.nih.gov/21370246/ http://hdl.handle.net/11452/23804 |
ISSN: | 0263-6484 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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