1. Açık Erişim@BUU
  2. İndeksli Yayınlar
  3. Web of Science
Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/23852
Başlık: Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Hemotoloji Anabilim Dalı.
Ozan, Hakan
Özkalemkaş, Fahir
Ozan, Ülkü
Özerkan, Kemal
Bilgin, Tevfik
Küçükyıldız, Faruk
AAG-8495-2021
AAH-9791-2021
7003908072
6601912387
6507254632
6603345841
7004103925
6504371550
Anahtar kelimeler: Filgrastim
Myelosuppression
Prechemotherapy
Topotecan
Colony-stimulating factor
Epithelial ovarian-Cancer
Granulocyte
Chemotherapy
Carcinoma
Invitro
Invivo
Cells
Csf
Oncology
Obstetrics & gynecology
Yayın Tarihi: 2001
Yayıncı: IMR Press
Atıf: Ozan, H. vd. (2001). "Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan". European Journal of Gynaecological Oncology, 22(6), 463-465.
Özet: Purpose: To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of topotecan-related myeloid suppression. Methods: No medication was given to 21 rats in group I; 1.5 mg/m(2)/day topotecan was administered intraperitoneally for five days every three weeks to 21 rats in group 11; a single dose of 5 mug/kg filgrastim was injected intraperitoneally 24 hours before the intraperitoneal administration of the same dose of topotecan to 21 rats in group M. After completion of six cycles of chemotherapy, the rats were decapitated and blood samples were immediately collected into citrated tubes for complete blood counts. Results: White blood cell and lymphocyte counts in the control and the filgrastim + topotecan groups were similar (p > 0.05) and significantly higher than the counts in the topotecan group (p < 0.05). There was no difference in means of neutrophil, monocyte, eosinophil, basophil and erythrocyte counts among the groups (p > 0.05). Conclusion: Filgrastim administration prior to chemotherapy seems to be beneficial and further investigations are needed.
URI: http://hdl.handle.net/11452/23852
ISSN: 0392-2936
Koleksiyonlarda Görünür:Scopus
Web of Science

Bu öğenin dosyaları:
Bu öğeyle ilişkili dosya bulunmamaktadır.
Tüm Öğe Kaydını Göster İstatistikler


DSpace'deki bütün öğeler, aksi belirtilmedikçe, tüm hakları saklı tutulmak şartıyla telif hakkı ile korunmaktadır.