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Başlık: Total and acylated ghrelin levels in type 2 diabetic patients: Similar levels observed after treatment with metformin, pioglitazone or diet therapy
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/ndokrinoloji ve Metabolizma Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-2593-7196
Kıyıcı, Sinem
Ersoy, Canan
Gül, Özen Öz
Sarandol, Emre
Demirci, Musa
Tuncel, Ercan
Sığırlı, Deniz
Ertürk, Erdinç
İmamoğlu, Sazi
AAH-8861-2021
AAJ-6536-2021
ABE-1716-2020
AAI-1005-2021
AAA-7472-2021
12753880400
6701485882
26040787100
55943324800
18534643800
7006929833
24482063400
7005488796
6602297533
Anahtar kelimeler: Ghrelin
Metformin
Pioglitazone
Type 2 diabetes
Circulating ghrelin
Food-intake
High-carbohydrate
Insulin therapy
Weight-gain
High-fat
Hormone
Peptide
Responses
Stomach
Endocrinology & metabolism
Yayın Tarihi: Eyl-2009
Yayıncı: Johann Ambrosius Barth Verlag
Atıf: Kıyıcı, S. vd. (2009). "Total and acylated ghrelin levels in type 2 diabetic patients: Similar levels observed after treatment with metformin, pioglitazone or diet therapy". Experimental and Clinical Endocrinology and Diabetes, 117(8), 386-390.
Özet: Ghrelin, a potent gut-brain orexigenic peptide, has a role in stimulation of food intake and long-term regulation of body weight. Metformin and pioglitazone treatment have different effects on body weight. This discrepancy might be related with the effect of these two drugs on plasma ghrelin levels. We investigated the effect of these two drugs on post-prandial acylated and total ghrelin levels in patients with type 2 diabetes. Eleven patients treated with diet, 12 patients treated with 850 mg/day metformin monotherapy and 12 patients treated with 30 mg/day pioglitazone monotherapy for at least 6 months were enrolled in the study. Plasma acylated and total ghrelin levels were investigated at baseline and at the 60(th), 120(th), 180(th), 240(th) minutes after a mixed meal test. There were no differences between groups in any of baseline metabolic and anthropometric parameters, including acylated and total ghrelin levels. Acylated and total ghrelin concentrations were suppressed similarly after food consumption, and we could not determine any significant difference between the groups at any time interval. A prolonged postprandial suppression of acylated ghrelin concentrations was observed in the pioglitazone treatment group compared with baseline values. In conclusion, total and acylated ghrelin levels after a mixed meal test were similar in type 2 diabetic patients treated with metformin, pioglitazone or diet therapy alone. These results suggest that changes in body weight during metformin and pioglitazone treatment are not associated with plasma ghrelin levels.
URI: https://doi.org/10.1055/s-0029-1220936
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0029-1220936
http://hdl.handle.net/11452/24009
ISSN: 0947-7349
Koleksiyonlarda Görünür:Scopus
Web of Science

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