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http://hdl.handle.net/11452/24137
Başlık: | Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. Egeli, Ünal 55665145000 |
Anahtar kelimeler: | Oncology Genetics & heredity Toxicology Pyrimethamine Sister chromatid exchanges Human lymphocyte culture Genotoxicity Toxoplasmosis Fragile sites Suspected aneugens SHL cells Cancer Rearrangements Invitro Aberrations Aneuploidy Gene |
Yayın Tarihi: | 1998 |
Yayıncı: | Wiley-Liss |
Atıf: | Egeli, Ü. (1998). "Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures". Teratogenesis Carcinogenesis and Mutagenesis, 18(4), 163-169. |
Özet: | This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes. |
URI: | https://doi.org/10.1002/(SICI)1520-6866(1998)18:4<163::AID-TCM2>3.0.CO;2-L https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1998)18:4%3C163::AID-TCM2%3E3.0.CO;2-L http://hdl.handle.net/11452/24137 |
ISSN: | 0270-3211 |
Koleksiyonlarda Görünür: | Web of Science |
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