Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures

Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/24137

Title:	Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures
Authors:	Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. Egeli, Ünal 55665145000
Keywords:	Oncology Genetics & heredity Toxicology Pyrimethamine Sister chromatid exchanges Human lymphocyte culture Genotoxicity Toxoplasmosis Fragile sites Suspected aneugens SHL cells Cancer Rearrangements Invitro Aberrations Aneuploidy Gene
Issue Date:	1998
Publisher:	Wiley-Liss
Citation:	Egeli, Ü. (1998). "Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures". Teratogenesis Carcinogenesis and Mutagenesis, 18(4), 163-169.
Abstract:	This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.
URI:	https://doi.org/10.1002/(SICI)1520-6866(1998)18:4<163::AID-TCM2>3.0.CO;2-L https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1998)18:4%3C163::AID-TCM2%3E3.0.CO;2-L http://hdl.handle.net/11452/24137
ISSN:	0270-3211
Appears in Collections:	Web of Science

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