Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/24169
Title: Identification of prognostic factors in patients with metastatic gastrointestinal stromal tumors
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.
0000-0002-9732-5340
Çubukçu, Erdem
Ölmez, Ömer Fatih
Avcı, Nilüfer
Canhoroz, Mustafa
Kurt, Ender
Kanat, Özkan
Evrensel, Türkkan
Manavoǧlu, Osman
AAJ-1027-2021
53986153800
26435400000
55390409800
52663246200
7006207332
55881548500
6603942124
6602587152
Keywords: Oncology
Gastrointestinal stromal tumors
Prognosis
S100 marker
Tumor location
Differential-diagnosis
Molecular pathology
Different sites
S100 proteins
Gist
Morphology
Consensus
Survival
Cancer
Issue Date: 2012
Publisher: Imprimatur Publications
Citation: Çubukçu, E. vd. (2012). "Identification of prognostic factors in patients with metastatic gastrointestinal stromal tumors". Journal of BUON, 17(3), 517-521.
Abstract: Purpose: Gastrointestinal stromal tumors (GISTs) have a complex biology which is reflected by a marked clinical heterogeneity. Thus, there has been great interest in identifying prognostic factors influencing tumor recurrence and survival. The aim of this study was to identify potential clinical and immunohistochemical prognostic factors that may affect survival and treatment outcomes inpatients with metastatic GISTs. Methods: Between 2000 and September 2011, a total of 41 patients with metastatic GISTs (29 males and 12 females; mean age: 57.4 +/- 11.8 years; range 29-74) were referred to the Department of Oncology, Uludag University Medical School. Survival analysis for a number of potential prognostic factors was made with the main outcome results of progression-free survival (PFS) and overall survival (OS). Results: The most common sites of isolated metastases comprised the liver (n=18), followed by lymph nodes (n=5), the omentum (n=1), and the mesothelium (n=1). The remaining patients had metastases at multiple sites. Cox regression analysis identified ileal location as the only significant predictor of poor PFS both after first-line (p=0.023) and second-line therapy (p=0.016). Tumor location in the ileum (p=0.025) and S100 immunoreactivity (p=0.041) were both independent predictors of OS. Conclusion: Tumor site and S100 positivity were the main significant independent predictors of clinical outcomes in patients with metastatic GISTs treated by standard of care.
URI: http://hdl.handle.net/11452/24169
ISSN: 1107-0625
2241-6293
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.