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Başlık: Effect of peripherally-injected glucagon-like peptide-1 on gastric mucosal blood flow
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
0000-0003-0863-1547
İşbil, Naciye Büyükcoşkun
Çam, Betül Etöz
Suyen, Güldal Güleç
Özlük, Kasım
C-5730-2015
AAH-1692-2021
55665951400
24179406800
6602752303
6602676331
Anahtar kelimeler: CGRP-(8-37)
Ethanol
Gastric mucosal blood flow
GLP-1
Indomethacin
L-NAME
Gene-related peptide
Experimental-models
Glp-1
Ethanol
Rat
System
Amide
Somatostatin
Involvement
Mechanisms
Endocrinology & metabolism
Physiology
Yayın Tarihi: 9-Eki-2009
Yayıncı: Elsevier
Atıf: İşbil, N. B. vd. (2009). "Effect of peripherally-injected glucagon-like peptide-1 on gastric mucosal blood flow". Regulatory Peptides, 157(1-3), 72-75.
Özet: The aim of this study was to investigate the mechanisms involved in the effect of glucagon-like peptide-1 (GLP-1) on the decrease in gastric mucosal blood flow (GMBF) induced by intragastric ethanol. After preparation of the stomach for GMBF recording, a probe was placed to the gastric mucosa and basal GMBF recordings were obtained by a laser Doppler flowmeter after a 30-minute stabilization period. Following GLP-1 (1000 ng/kg; i.p.) injection, 1 ml of absolute ethanol was applied to the gastric chamber and GMBF was recorded continuously during a 30-minute period. GLP-1 (1000 ng/kg; i.p.) prevented the decrease in GMBF induced by ethanol. Nitric oxide (NO) synthase inhibitor L-NAME, (30 mg/kg; s.c.), calcitonine gene-related peptide (CGRP) receptor antagonist CGRP-(8-37) (10 mu g/kg; i.p.), and cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.) all inhibited the GMBF-improving effect of GLP-1. We concluded that, NO, CGRP and prostaglandins may be involved in the effect of peripherally-injected GLP-1 on GMBF reduction induced by intraluminal ethanol.
URI: https://doi.org/10.1016/j.regpep.2009.04.013
https://www.sciencedirect.com/science/article/pii/S0167011509000913
http://hdl.handle.net/11452/24263
ISSN: 0167-0115
Koleksiyonlarda Görünür:Scopus
Web of Science

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