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Başlık: Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-2593-7196
0000-0002-8974-8837
Şentürk, Tunay
Sarandöl, Emre
Güllülü, Sümeyye
Erdinç, Selda
Özdabakoğlu, Osman
Özdemir, Bülent
Baran, İbrahim
Arslan, Sinan
Aydınlar, Ali
C-1517-2017
ABE-1716-2020
AAI-6632-2021
8342098300
55943324800
57204660708
24334883200
25221805700
7004168959
35572557400
57198213690
6603131517
Anahtar kelimeler: C-reactive protein
Low-density-lipoprotein
Acute-phase response
Paraoxonase activity
Myocardial-infarction
Unstable angina
Atherosclerosis
Oxidation
Plasma
Mice
General & internal medicine
Yayın Tarihi: Mar-2009
Yayıncı: Saudi Med J
Atıf: Şentürk, T. vd. (2009). "Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes". Saudi Medical Journal, 30(3), 334-339.
Özet: Objectives: To examined whether serum paraoxonase (PON1) and arylesterase (ARE) activities are correlated with inflammatory biomarkers (procalcitonin and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). Methods: This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation: unstable angina pectoris (UAP) (Braunwald III-B, n=25), non-ST elevation myocardial infarction (NSTEMI) (n=18), and ST-elevation myocardial infarction (STEMI) (n=35). Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay. Results: Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin (r=-0.577, p=0.009, and r=-0.642, p=0.019) and hs-CRP levels (r=-0.614, p=0.03, and r=-0.719, p=0.044). Conclusion: Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers.
URI: http://hdl.handle.net/11452/24601
ISSN: 0379-5284
Koleksiyonlarda Görünür:Scopus
Web of Science

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