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Başlık: Induction of anesthesia in coronary artery bypass graft surgery: The hemodynamic and analgesic effects of ketamine
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.
0000-0002-1190-6831
0000-0002-3019-581X
Başağan Moğol, Elif
Gören, Suna
Korfali, Gülşen
Türker, Gürkan
Kaya, Fatma Nur
AAI-8213-2021
AAI-3551-2021
AAI-6642-2021
23982134100
7006563257
6701462594
7003400116
7003619647
Anahtar kelimeler: Coronary artery bypass grafting
Ketamine
Propofol
Fentanyl
Midazolam
Cardiac surgical patients
Diazepam
General & internal medicine
Yayın Tarihi: Şub-2010
Yayıncı: Hospital Clinicas, Univ Sao Paulo
Atıf: Başağan, Moğol, E. vd. (2010). "Induction of anesthesia in coronary artery bypass graft surgery: The hemodynamic and analgesic effects of ketamine". Clinics, 65(2), 133-138.
Özet: OBJECTIVE: The aim of this prospective, randomized study was to evaluate the hemodynamic and analgesic effects of ketamine by comparing it with propofol starting at the induction of anesthesia until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery. INTRODUCTION: Anesthetic induction and maintenance may induce myocardial ischemia in patients with coronary artery disease. A primary goal in the anesthesia of patients undergoing coronary artery bypass grafting surgery is both the attenuation of sympathetic responses to noxious stimuli and the prevention of hypotension. METHODS: Thirty patients undergoing coronary artery bypass grafting surgery were randomized to receive either ketamine 2 mg.kg(-1) (Group K) or propofol 0.5 mg.kg(-1) (Group P) during induction of anesthesia. Patients also received standardized doses of midazolam, fentanyl, and rocuronium in the induction sequence. The duration of anesthesia from induction to skin incision and sternotomy, as well as the supplemental doses of fentanyl and sevoflurane, were recorded. Heart rate, mean arterial pressure, central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index, systemic and pulmonary vascular resistance indices, stroke work index, and left and right ventricular stroke work indices were obtained before induction of anesthesia; one minute after induction; one, three, five, and ten minutes after intubation; one minute after skin incision; and at one minute after sternotomy. RESULTS: There were significant changes in the measured and calculated hemodynamic variables when compared to their values before induction. One minute after induction, mean arterial pressure and the systemic vascular resistance index decreased significantly in group P (p<0.01). CONCLUSION: There were no differences between groups in the consumption of sevoflurane or in the use of additional fentanyl. The combination of ketamine, midazolam, and fentanyl for the induction of anesthesia provided better hemodynamic stability during induction and until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery.
URI: https://doi.org/10.1590/S1807-59322010000200003
https://www.scielo.br/j/clin/a/Swh8rNzmNCkVLqxg6kTjYRh/abstract/?lang=en
http://hdl.handle.net/11452/24752
ISSN: 1807-5932
Koleksiyonlarda Görünür:Scopus
Web of Science

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