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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25089
Title: 5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Gülten, Tuna
Yakut, Tahsin
Güneş, Adalet Meral
Demirkaya, Metin
6505944216
6602802424
24072843300
24331130000
Keywords: MLL gene deletion
Acute Lymphoblastic Leukemia
FISH analysis
Hemotological malignancies
Rearrangement
Translocations
Identification
Abnormalities
Aberrations
Apoptosis
11Q23
Probe
Fish
Medical laboratory technology
Issue Date: Feb-2010
Publisher: Oxford University
Citation: Gülten, T. vd. (2010). "5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia". Laboratory Medicine, 41(2), 83-86.
Abstract: Myeloid/lymphoid leukemia (MLL) gene rearrangements are high risk cytogenetic characteristics of acute lymphoblastic leukemia (ALL). Translocations of this gene are well defined, and their impact on the patient's prognosis is well known, but deletions of the same region are rare, and little is known about their prognostic significance and the significance of their accompanying translocations. Here we present a case of childhood ALL with a deletion of the 5' region of the MILL gene detected by fluorescence in situ hybridization (FISH) analysis, This result also confirmed the sensitivity and efficiency of FISH analysis.
URI: https://doi.org/10.1309/LMC5LW0IMKNG5LCN
https://academic.oup.com/labmed/article/41/2/83/2504871
http://hdl.handle.net/11452/25089
ISSN: 0007-5027
Appears in Collections:Scopus
Web of Science

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