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Başlık: Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı/Neonatoloji Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.
0000-0002-4606-6596
0000-0003-3368-8123
Özyener, Fadıl
Çetinkaya, Merih
Alkan, Tülin
Gören, Bülent
Kafa, İlker Mustafa
Kurt, Mustafa Ayberk
Köksal, Nilgün
AAH-1792-2021
AAH-1718-2021
AAG-8393-2021
AAH-1641-2021
AAG-7125-2021
AAR-4341-2020
6506242143
23994946300
6601953747
6602543716
8450193200
35603735000
7003323615
Anahtar kelimeler: Neurosciences & neurology
Combination therapy
Hypoxia-ischemia
Melatonin
Neuroprotection
Topiramate
Brain-damage
Protective role
Cell-death
Newborn
Injury
Reduction
Infant
Yayın Tarihi: 2012
Yayıncı: IOS Press
Atıf: Özyener, F. vd. (2012). "Neuroprotective effects of melatonin administered alone or in combination with topiramate in neonatal hypoxic-ischemic rat model". Restorative Neurology and Neuroscience, 30(5), 435-444.
Özet: Purpose: The objective of this study was to compare the effects of two neuroprotective agents; melatonin, a free radical scavenger and topiramate, AMPA/kainate receptor antagonist, administered alone or in combination in neonatal hypoxic-ischemic model. Methods: After being anesthetized, 7-day-old pups underwent ischemia followed by exposure to hypoxia. The pups were divided into 4 groups in order to receive the vehicle, melatonin, topiramate and combination of topiramate and melatonin. These were administered intraperitoneally for three times; the first before ischemia, the second after hypoxia and the third 24 hours after the second dose. After sacrification, infarct volume and apoptosis were evaluated. Results: Percent infarcted brain volume was significantly reduced in rats which received drugs compared with those which received the vehicle. The number of TUNEL positive cells per unit area in hippocampus and cortex were markedly reduced in drug treated groups compared with control group. No significant differences were found regarding percent infarcted brain volume and number of TUNEL positive cells among drug-treated groups. Conclusions: Melatonin and topiramate, administered either alone or in combination significantly reduced the percent infarcted brain volume and number of TUNEL positive cells suggesting that these agents may confer benefit in treatment of infants with hypoxic-ischemic encephalopathy.
URI: https://doi.org/10.3233/RNN-2012-120217
https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn120217
http://hdl.handle.net/11452/25311
ISSN: 0922-6028
1878-3627
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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