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Başlık: Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene i/d and glutathione-s-transferase enzyme t1 and m1 with retinopathy of prematures
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Yıldız, Meral
Karkucak, Mutlu
Yakut, Tahsin
Görükmez, Özlem
Özmen, Ahmet Tuncer
AAH-1885-2021
35791194600
35388323500
6602802424
57188923466
6701399730
Anahtar kelimeler: Polymorphism
ACE gene
GSTT1
GSTM1
Retinopathy of prematurity
Norrie-disease gene
Endothelial growth-factor
Birth-weight infants
Insertion/deletion polymorphism
Missense mutations
Null genotypes
Sleep-apnea
Risk
Progression
Fibrinolysis
Biochemistry & molecular biology
Genetics & Heredity
Yayın Tarihi: 2010
Yayıncı: Funpec-Editora
Atıf: Yıldız, M. vd. (2010). "Lack of association of genetic polymorphisms of angiotensin-converting enzyme gene i/d and glutathione-s-transferase enzyme t1 and m1 with retinopathy of prematures". Genetics and Molecular Research, 9(4), 2131-2139.
Özet: One of the most frequently observed causes of blindness in infancy is the pathogenesis known as retinopathy of prematurity (ROP). Angiotensin-converting enzyme (ACE) is a vital enzyme in the renin-angiotensin-aldosterone system; it is involved in the development of cardiovascular system diseases linked to I/D polymorphism of the ACE gene. Glutathione-S-transferase enzyme (GST) is one of the most important regulating components of the antioxidant system; there are indications that certain polymorphisms of GST genes (GSTT1, GSTM1), especially the null genotypes, increase the tendency for oxidative stress diseases. We investigated a possible correlation between ACE gene I/D and GSTT1 and GSTM1 gene polymorphisms in 56 prematures suffering from ROP and a control group composed of 48 prematures without ROP in a hospital in Turkey. PCR was used to detect the ACE I/D, GSTT1 and GSTM1 gene polymorphisms. Genotype was determined based on bands formed on agarose gel electrophoresis. We found no significant differences in genotype frequency of the ACE I/D, GSTT1 and GSTM1 genes between normal subjects and patients with ROP. Our results do not support an association of ACE I/D, GSTT1 and GSTM1 gene polymorphisms with risk for ROP.
URI: https://doi.org/10.4238/vol9-4gmr887
http://hdl.handle.net/11452/25317
ISSN: 1676-5680
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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