Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25470
Title: Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis
Authors: Zachou, Kalliopi
Yurdaydın, Cihan
Drebber, Uta
Dalekos, George Nikolaos
Erhardt, Andreas
Çakaloğlu, Yılmaz
Değertekin, Halil
Zeuzem, Stefan S.
Bozkaya, Hakan
Schlaphoff, Verena
Dienes, Hans Peter
Bock, C. Thomas
Manns, Michael Peter
Wedemeyer, Heiner
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Gürel, Selim
7003706434
Keywords: Chronic hepatitis delta
HDV-RNA
PCR
Quantitative HBsAg
Polymerase-chain-reaction
D virus-infection
Real-time pcr
B-virus
Vanishing disease
Serum
Transmission
Interferon
Lamivudine
Therapy
Gastroenterology & hepatology
Issue Date: Mar-2010
Publisher: Wiley
Citation: Zachou, K. vd. (2010). "Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis". Liver International, 30(3), 430-437.
Abstract: Background: Hepatitis delta virus (HDV) causes severe liver disease. Aims: To investigate the quantitative HDV-RNA, HBsAg and hepatitis B virus (HBV)DNA levels in correlation to histological, biochemical and demographical parameters in patients with chronic HDV infection as similar data in a large series of HDV patients are missing. Methods: Eighty HDV patients were recruited in Germany, Turkey and Greece; quantitative determination of HDV-RNA, HBsAg and HBV-DNA was performed by real-time polymerase chain reaction, the Architect HBsAg assay and Cobas TaqMan HBV test respectively. Results: All patients were infected with HDV-genotype 1. Thirty-five patients (48%) had significant fibrosis (Ishak 3-4) and 15 (20.5%) had cirrhosis. HDV viraemia ranged from 1.1 x 10(3) to 8.4 x 10(7) copies/ml with 60% of patients showing HDV-RNA levels above 105 copies/ml accompanied by low HBV viraemia (<10(5) copies/ml). However, HDV-RNA and HBV-DNA levels showed no direct inverse correlation. HDV-RNA correlated positively with HBsAg and negatively with age. HBsAg correlated negatively with age and positively with histological grading. Only gamma-glutamyltranspeptidase was independently associated with cirrhosis (P=0.032), while no biochemical parameter was associated with grading. Conclusions: (i) HBsAg levels correlated with HDV viraemia in chronic HDV. (ii) Biochemical parameters did not accurately indicate the stage and grade of liver disease in chronic HDV and thus liver biopsy seems to remain the major tool for the evaluation of delta hepatitis patients.
URI: https://doi.org/10.1111/j.1478-3231.2009.02140.x
https://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2009.02140.x
http://hdl.handle.net/11452/25470
ISSN: 1478-3223
1478-3231
Appears in Collections:Scopus
Web of Science

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