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Başlık: XRCC1 gene polymorphisms and risk of lung cancer in Turkish patients
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.
0000-0002-9732-5340
Karkucak, Mutlu
Yakut, Tahsin
Evrensel, Türkkan
Deligönül, Adem
Gülten, Tuna
Ocakoğlu, Gökhan
Kurt, Ender
Kanat, Özkan
Çubukcu, Erdem
Şehitoğlu, İbrahim
Canhoroz, Mustafa
AAJ-1027-2021
AAH-5180-2021
ABF-8955-2021
35388323500
6602802424
6603942124
37088030300
6505944216
15832295800
7006207332
55881548500
53986153800
36553239400
52663246200
Anahtar kelimeler: Genetics & heredity
Polymorphism
XRCC1
Lung cancer
Dna-repair genes
Excision-repair
Population
Xpd
Susceptibility
Association
Metaanalysis
Frequency
Pathway
Yayın Tarihi: Haz-2012
Yayıncı: Kamla-Raj Enterprises
Atıf: Karkucak, M. vd. (2012). "XRCC1 gene polymorphisms and risk of lung cancer in Turkish patients". International Journal of Human Genetics, 12(2), 113-117.
Özet: Polymorphisms in the X-ray repair cross complementing 1 (XRCC1) gene have been found to be associated with susceptibility to various types of cancers. We investigated the association between the XRCC1 gene Arg399Gln polymorphism and the susceptibility to lung cancer in Turkish patients. To determine the association of this polymorphism with the risk of lung cancer in Turkish patients, a hospital-based case-control study was designed, involving 67 patients with lung cancer and 60 control subjects with no cancer history who were matched for age and gender. XRCC1 genotypes (Arg/Arg, Arg/Gln, and Gln/Gln) were determined using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis on genomic DNA. No statistically significant relationship was determined between the lung cancer and control groups (p>0.05). Among the patients, 61% were Arg/Arg, 28% were Arg/Gln, and 11% were Gln/Gln. Among the controls, 50% were Arg/Arg, 38% were Arg/Gln, and 12% were Gln/Gln. There was no difference in the distribution of XRCC1 genotypes or the frequencies of the Arg (75% versus 69%) and Gln (25% versus 31%) alleles between the lung cancer patients and controls. Our results suggest that the XRCC1 gene Arg399Gln polymorphism is not associated with an increased risk for the development of lung cancer in Turkish patients.
URI: https://doi.org/10.1080/09723757.2012.11886171
https://www.tandfonline.com/doi/abs/10.1080/09723757.2012.11886171
http://hdl.handle.net/11452/25491
ISSN: 0972-3757
Koleksiyonlarda Görünür:Scopus
Web of Science

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