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Başlık: Glycogen phosphorylase isoenzyme BB in early diagnosis of acute coronary syndrome
Diğer Başlıklar: Akut koroner sendromun erken tanisinda glikojen fosforilaz izoenzim BB
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
0000-0002-2593-7196
0000-0002-0909-618X
0000-0003-0297-846X
Serdar, Zehra
Altın, Aysun
Serdar, Akın
Bilgili, Gökhan
Sarandöl, Emre
Doğruk, Elif Emre
Armağan, Erol
Özkaya, Güven
ABE-1716-2020
AAH-6200-2021
A-4421-2016
AAH-8846-2021
57222002284
17134032300
6603403111
35077543700
55943324800
55355828300
6506464232
16316866500
Anahtar kelimeler: General & internal medicine
Acute coronary syndrome
Glycogen phosphorylase bb
Troponin I
Creatine kinase mb
Myoglobin
Acute myocardial-infarction
Biochemical markers
Cardiac biomarkers
Chest-pain
Troponin-t
Myoglobin
Release
Mass
Akut koroner sendrom
Glikojen fosforilaz BB
Kreatin kinaz MB
Miyoglobin
Yayın Tarihi: 2012
Yayıncı: Nobel İlaç
Atıf: Serdar, Z. vd. (2012). "Glycogen phosphorylase isoenzyme BB in early diagnosis of acute coronary syndrome". Nobel Medicus, 8(2), 65-72.
Özet: Objective: To investigate the usefulness and diagnostic performance of glycogen phosphorylase BB (GPBB) to aid early diagnosis of acute coronary syndrome and to compare with cardiac-specific troponin I (cTnI), creatine kinase isoenzyme MB and myoglobin. Material and Method: Non-traumatized 72 patients arriving at the emergency department within 3 hours after the onset of chest pain suggestive of acute coronary syndrome were included. The patients were classified as having acute myocardial infarction (AMI) or unstable angina pectoris (UAP). Blood samples were obtained on arrival (0 hours), 6 hours, and 24 hours. To determine the diagnostic performances of GPBB and other cardiac markers for ACS, sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and receiver operating characteristic (ROC) curves with areas under curves were calculated. Results: Seventy two non-traumatic chest pain patients and 45 controls were enrolled. GPBB was the most sensitive biochemical cardiac marker of all tested in AMI and UAP patients on admission, whereas its specificity was low In both AMI and UAP patients, the area under the GPBB ROC curve, was significantly greater than the areas under all other ROC curves on admission. Conclusion: GPBB is a promising enzyme for the early laboratory detection of ischemic myocardial damage. Because the diagnostic specificity of GPBB for myocardial damage is low, a positive GPBB result should subsequently be confirmed by cTnI measurement. However; further studies on specificity and development of a fast, automated assay are necessary before GPBB can be recommended as a routine diagnostic tool.
URI: https://www.nobelmedicus.com/en/Article.aspx?m=337
http://hdl.handle.net/11452/25635
ISSN: 1305-2381
Koleksiyonlarda Görünür:Scopus
Web of Science

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