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http://hdl.handle.net/11452/25656
Başlık: | Molecular cytogenetic findings in cases with childhood acute lymphoblastic leukemia |
Diğer Başlıklar: | Çocukluk çaği akut lenfoblastik lösemili olgularda moleküler sitogenetik bulgular |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematolojisi Anabilim Dalı. Karkucak, Mutlu Görukmez, Orhan Yakut, Tahsin Baytan, Birol Görükmez, Özlem Güneş, Adalet Meral AFZ-0764-2022 35388323500 56681045900 6602802424 6506622162 57188923466 24072843300 |
Anahtar kelimeler: | Oncology Acute lymphoblastic leukemia Molecular cytogenetic Chromosomal anomaly High hyperdiploidy Children Rearrangements Abnormalities Genes P15 Akut lenfoblastik lösemi Kromozomal anomali Moleküler sitogenetik |
Yayın Tarihi: | 2012 |
Yayıncı: | Akad Doktorlar Yayınevi |
Atıf: | Karkucak, M. vd. (2012). "Molecular cytogenetic findings in cases with childhood acute lymphoblastic leukemia". UHOD-Uluslararasi Hematoloji-Onkoloji Dergisi, 22(2), 67-72. |
Özet: | Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and is usually associated with numerical and structural chromosomal changes. Although some of these changes are accepted as favorable or poor prognostic factors, the prognostic effects of others have not been well determined. In our study, we aimed to present the chromosomal changes in cases with childhood ALL and their ratios in hematologic risk groups. Thirty four patients with childhood ALL were included in the study. Subjects were diagnosed with fluorescence in situ hybridization (FISH) analysis by using standard translocation, deletion and aneuploidy probes. The chromosomal changes obtained from our analysis were classified into hematologic risk groups and their ratios were evaluated. In our study, we found that the t(12.21) translocation was the most common abnormality in minimal and standard risk groups, whereas the 9p21 deletion was the most common abnormality among high-risk patients. |
URI: | https://doi.org/10.4999/uhod.11045 http://www.uhod.org/pdf/PDF_516.pdf http://hdl.handle.net/11452/25656 |
ISSN: | 1306-133X |
Koleksiyonlarda Görünür: | Scopus TrDizin Web of Science |
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