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Başlık: Effect of cycline D1 (CCND1) gene polymorphism on tumor formation and behavior in patients with prolactinoma
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
Cander, Soner
Ertürk, Erdinç
Karkucak, Mutlu
Gül, Özen Öz
Görükmez, Orhan
Yakut, Tahsin
Ünal, Oğuz Kaan
Ersoy, Canan
Tuncel, Ercan
İmamoğlu, Şazi
AAI-1005-2021
AAH-8861-2021
AAJ-6536-2021
25027068600
7005488796
35388323500
26040787100
56681045900
6602802424
55042241400
6701485882
7006929833
6602297533
Anahtar kelimeler: Genetics & heredity
Prolactinoma
Polymorphism
Invasiveness
CCND1
Sporadic pituitary-adenomas
Breast-cancer
Lung-cancer
Expression
Overexpression
Classification
Carcinoma
Genotype
Biology
Yayın Tarihi: 1-Kas-2012
Yayıncı: Elsevier
Atıf: Cander, S. vd. (2012). "Effect of cycline D1 (CCND1) gene polymorphism on tumor formation and behavior in patients with prolactinoma". Gene, 509(1), 158-163.
Özet: The objective of this study was to investigate the effect of G870A gene polymorphism of CCND1 on the formation and behavioral features of prolactinomas. One hundred and thirteen patients with prolactinoma and 108 age and gender matched control were included in the study. The patients were divided into two groups as noninvasive and invasive tumors. CCND1 G870A gene polymorphism was compared in patients/control and invasive/noninvasive groups. A and G allele frequencies were found as 41.7% and 58.3% in the controls, and 61.1% and 38.9% in the patients (p<0.01). Rates of G/G, G/A and A/A genotypes were found as 11.8%, 55.9% and 32.4% in the noninvasive group, and 15.6%, 44.4% and 40.0% in the invasive group, respectively. Differences between patient and control groups were significant but were not between invasive and noninvasive groups in terms of the allele frequencies and genotype distribution. Mean tumor size and serum levels of prolactin at the time of diagnosis and change in these values after the treatment were not found statistically significant in genotype subgroups. CCND1 G870A gene polymorphism may be an important factor in the early stages of the tumor formation. However, it did not affect the features of the tumor.
URI: https://doi.org/10.1016/j.gene.2012.07.056
https://www.sciencedirect.com/science/article/pii/S0378111912009079
http://hdl.handle.net/11452/25681
ISSN: 0378-1119
1879-0038
Koleksiyonlarda Görünür:Web of Science

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