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Başlık: Analysis of TNF-alpha G308A and C857T gene polymorphisms in Turkish patients with obstructive sleep apnea syndrome
Diğer Başlıklar: Obstrüktif uyku apne sendromu olan türk hastalarda TNF-alfa G308A ve C857T gen polimorfizmlerinin incelenmesi
Yazarlar: Karkucak, Mutlu
Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
0000-0002-9027-1132
0000-0002-2382-290X
Ursavaş, Ahmet
Ocakoğlu, Gökhan
Görükmez, Orhan
Yakut, Tahsin
Ercan, İlker
Karadağ, Mehmet
AAG-8744-2021
AAI-3169-2021
AAH-5180-2021
8329319900
15832295800
56681045900
6602802424
6603789069
6601970351
Anahtar kelimeler: General & internal medicine
Polymorphism, single nucleotide
Sleep apnea, obstructive
Angiotensin-converting enzyme
Cardiovascular-disease
Promoter polymorphism
Association
Cytokines
Obesity
Arthritis
Alleles
Region
Yayın Tarihi: Eki-2012
Yayıncı: Ortadogu Yayınevi
Atıf: Karkucak, M. vd. (2012). "Analysis of TNF-alpha G308A and C857T gene polymorphisms in Turkish patients with obstructive sleep apnea syndrome". Türkiye Klinikleri Tıp Bilimleri Dergisi, 32(5), 1368-1373.
Özet: Objective: Tumor necrosis factor-alpha (TNF-alpha) is an important indicator of inflammation. Recent studies have demonstrated a relationship between inflammation and obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the association between TNF-alpha G308A and C857T gene polymorphisms and OSAS in Turkish patients. Material and Methods: Sixty-nine patients who were diagnosed with OSAS and 42 control subjects were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect TNF-alpha G308A and C857T gene polymorphisms. The level of significance for statistical analysis was set at p<0.05. Results: The distribution of genotypes was not significantly different between subjects with a definite diagnosis of OSAS and the control group (p> 0.05). However, the mean body mass index of the OSAS group was significantly different from that of the control group (p<0.05). Conclusion: To our knowledge, this study is the first to analyze the relationship between OSAS and INF-alpha G308A and C857T gene polymorphisms in Turkish patients. Our results do not support an association between OSAS and TNF-alpha G308A and C857T gene polymorphisms.
URI: https://doi.org/10.5336/medsci.2012-28126
https://www.turkiyeklinikleri.com/article/en-analysis-of-tnf-alpha-g308a-and-c857t-gene-polymorphisms-in-turkish-patients-with-obstructive-sleep-apnea-syndrome-63032.html
http://hdl.handle.net/11452/25696
ISSN: 1300-0292
Koleksiyonlarda Görünür:Scopus
Web of Science

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