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Başlık: Polymorphisms in angiotensin-converting enzyme and glutathione s-transferase genes in Turkish population and risk for preeclampsia
Yazarlar: Develioǧlu, Osman H.
Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
0000-0002-9685-956X
Atalay, Mehmet Aral
Özerkan, Kemal
Karkucak, Mutlu
Yakut, Tahsin
Atik, Yeliz
A-8779-2013
AAH-9791-2021
53863297800
6603345841
35388323500
6602802424
55566559900
Anahtar kelimeler: Obstetrics & gynecology
Gene
Polymorphism
Angiotensin-converting enzyme
Glutathione s-transferase
Preeclampsia
Peroxidase activity
Ace-i/d
Pregnancy
Renin
Association
System
Yayın Tarihi: 2012
Yayıncı: Imr Press
Atıf: Atalay, M. A. vd. (2012). "Polymorphisms in angiotensin-converting enzyme and glutathione s-transferase genes in Turkish population and risk for preeclampsia". Clinical and Experimental Obstetrics and Gynecology, 39(4), 466-469.
Özet: Aims: This study was conducted to investigate whether insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene and polymorphisms in glutathione S-transferase (GST) M1 and T1 genes are associated with increased risk for preeclampsia. Materials and Methods: Sixty-three patients with hypertensive disorder of pregnancy and 85 controls were evaluated in a prospective case-control study. All subjects were genotyped by polymerase chain reaction (PCR) followed by agarose gel electrophoresis. Results: Allele frequencies of ACE gene I/D polymorphism were found significantly different between preeclampsia and the control groups (p = 0.001). Differences in genotype frequencies of ACE gene LID polymorphism between the two groups were statistically significant (p = 0.004). Individuals homozygous for D allele were more likely to develop preeclampsia (OR = 2.29; 95% CI, 1.39 - 3.79), whereas heterozygous individuals were not at increased risk (OR = 0.92; 95% Cl, 0.56 - 1.49), compared to individuals homozygous for I allele. The differences in frequencies of functional and null alleles of GSTM1 and GSTT1 genes between the two groups were not significant (p = 0.46 and p = 0.44, respectively). Conclusion: ACE gene DD genotype was found to be associated with increased risk of preeclampsia development, whereas the authors did not find any significant relationship with polymorphisms of the GSTM1 and GSTT1 genes and preeclampsia.
URI: https://ceog.imrpress.com/EN/abstract/abstract6713.shtml
http://hdl.handle.net/11452/25817
ISSN: 0390-6663
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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