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Başlık: Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes
Yazarlar: Munne, Santiago
Held, Karsten R.
Magli, Cristina M.
Wells, Dagan
Fragouli, Elpida
Baukloh, Vera
Fischer, Robert
Gianaroli, Luca
Uludağ Üniversitesi/Tıp Fakültesi.
0000-0003-1106-3747
Ata, Barış
C-8049-2013
16306205100
Anahtar kelimeler: Obstetrics & gynecology
Reproductive biology
Pgd
Preimplantation genetic diagnosis
Aneuploidy
Cryopreservation
Fertility preservation
Cancer
Pgs
Preimplantation genetic diagnosis
Metaphase-II oocytes
Maternal age
Donation program
Pregnancy rates
Clinical-trial
Embryos
Vitrification
Biopsy
Yayın Tarihi: Nis-2012
Yayıncı: Elsevier Science
Atıf: Munne, S. vd. (2012). "Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes". Fertility and Sterility, 97(4), 935-942.
Özet: Objective: To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year. Design: Retrospective study. Setting: Fertility centers. Patient(s): Infertile couples undergoing IVF. Intervention(s): Patients underwent two consecutive cycles of preimplantation genetic screening through first polar body biopsy within 1 year. Main Outcome Measure(s): Meiosis I aneuploidy. Result(s): A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than +/- 2 euploid eggs of difference between cycles. Conclusion(s): Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have. This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.
URI: https://doi.org/10.1016/j.fertnstert.2012.01.106
https://www.sciencedirect.com/science/article/abs/pii/S0015028212001562
http://hdl.handle.net/11452/25870
ISSN: 0015-0282
1556-5653
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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