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Başlık: Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.
0000-0003-0463-6818
0000-0003-0463-6818
0000-0002-7400-9089
0000-0002-7400-9089
Ursavaş, Ahmet
Karadağ, Mehmet
Oral, Arzu Yılmaztepe
Demirdöǧen, Ezgi Şen
Oral, Haluk Barbaros
Ege, Ercüment
AAI-3169-2021
A-5841-2017
AAG-8744-2021
AAH-9812-2021
K-7285-2012
8329319900
6601970351
23091316500
14062849300
7004498001
6701341320
Anahtar kelimeler: Cardiovascular system & cardiology
Respiratory system
Daytime sleepiness
Neopterin
Obesity
Sleep apnea
Acute coronary syndromes
Insulin-resistance
Artery-disease
Risk-factor
Kappa-b
Thickness
Marker
System
Yayın Tarihi: Ağu-2008
Yayıncı: W B Saunders
Atıf: Ursavaş, A. vd. (2008). ''Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea". Respiratory Medicine, 102(8), 1193-1197.
Özet: Objective: Obesity and obstructive sleep apnea (OSA) and systemic inflammation may interact through biochemical pathways. Neopterin (NP) is a monocyte/macrophage activation marker produced by macrophages in response to interferon-gamma secreted by activated T lymphocytes. This study examines the association between NP, obesity and OSA. Patients and methods: The study included 22 newly diagnosed OSA (+) patients and 18 OSA patients. Subjects with history of coronary artery disease, transplant patients, history of alcohol and drug abuse, history of HIV and any other significant medical. illnesses such as active infections, autoimmune disease, malignancy, liver disease, pulmonary disease (COPD, asthma, ...), neuromuscular disease, patients on immunomodulating therapy or HMG-CoA reductase inhibitors were excluded. Results: There were no significant differences in age, body mass index (BMI), and smoking habits of the OSA (+) patients and OSA (-) patients. Serum NP levels did not show any significant difference between the OSA (+) patients and OSA (-) patients, however, NP levels were positively correlated with BMI (r = 0.320, p = 0.044). There was no significant correlation between NP and any of the polysomnographic parameters. The result of stepwise regression analyses (r 2 = 0.320, p < 0.001) showed that high serum NP levels (p = 0.004) and apnea-hypopnea index (AHI) were a risk factor for elevated Epworth sleepiness score, independent of BMI. Conclusion: We suggest that serum NP levels correlate with BMI. There was a significant relationship between serum NP levels and excessive daytime sleepiness in OSA patients.
URI: https://doi.org/10.1016/j.rmed.2008.02.019
https://www.sciencedirect.com/science/article/pii/S0954611108000954
http://hdl.handle.net/11452/26011
ISSN: 0954-6111
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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