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Başlık: Comparison of tumor markers and clinicopathological features in serous and mucinous borderline ovarian tumors
Yazarlar: Alanbay, İbrahim
Aktürk, Erhan
Çoksüer, Hakan
Ercan, Cihangir Mutlu
Karaşahin, Kazım Emre
Dede, Murat
Yenen, Müfit Cemal
Dilek, Saffet
Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
Ozan, Hakan
7003908072
Anahtar kelimeler: Oncology
Obstetrics & gynecology
Borderline ovarian tumor
Serous
Mucinous borderline ovarian tumor
Tumor markers
Ca 125
Multivariate-analysis
Ca-125 levels
Management
Yayın Tarihi: 2012
Yayıncı: Imr Press
Atıf: Alanbay, İ. vd. (2012). "Comparison of tumor markers and clinicopathological features in serous and mucinous borderline ovarian tumors". European Journal of Gynaecological Oncology, 33(1), 25-30.
Özet: Objective: The aim of this study was to assess tumor markers and clinicopathological findings of patients with serous and mucinous borderline ovarian tumor (BOT) features. Methods: The study consisted of 50 patients that were diagnosed with and treated for BOT between 2005- 2010 in three centers. CA125, CA19-9, and CA125+CA19-9 levels and clinicopathological features were compared in serous and mucinous histotypes. In serous and mucinous BOTs, correlations between tumor markers and demographics such as age, menopausal status, parity, clinical findings (stage, relapse, adjuvant chemotherapy, cytology, lymph node involvement and tumoral morphology (cystic-solid content, papilla, septation) were evaluated. Results: There were no significant differences between serous and mucinous tumors in the clinicopathological features such as stage, tumor markers, age, menopausal status, or cytology. In serous BOTs we found a significant relation between elevated CA 125+ CA 19-9, CA 19-9 and recurrence (p<0.05). Also there was a significant relation between elevated CA 125+ CA 19-9, CA 19-9 and cytology positivity (p<0.05). We found a significant relation in serous BOTs between elevated CA125+CA19-9, adjuvant chemotherapy and lymph node metastases (p<0.05). Also In mucinous BOTs with papilla formation we found a significant relation between elevated CA125 and CA 125+ CA19-9 (p<0.05). There was significant relation between cytology positivity and elevated CA 19-9 in mucinous BOTs (p<0.05). Conclusion: Serum tumor markers of serous and mucinous BOTs were different in relation to their clinicopathological features. This may reflect differences of serous and mucinous BOTs.
URI: http://hdl.handle.net/11452/26325
ISSN: 0392-2936
Koleksiyonlarda Görünür:Scopus
Web of Science

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