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Başlık: Neutrophil-to-lymphocyte ratio in obstructive sleep apnea; a multi center, retrospective study
Yazarlar: Altıntaş, Nejat
Yüceege, Melike Bağnu
Fırat, Hikmet
Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
0000-0002-9027-1132
Çetinoğlu, Ezgi Demirdöğen
Acet, A. N.
Ursavaş, Ahmet
Karadaǧ, Mehmet
AAI-3169-2021
AAG-8744-2021
57189524206
57212943552
8329319900
6601970351
Anahtar kelimeler: C-reactive protein
Inflammation
Neutrophil/lymphocyte ratio
Obstructive sleep apnea
C-reactive protein
Systemic inflammation
Myocardial-infarction
Cardiovascular risk
Predict
Adiponectin
Mortality
Failure
Markers
Obesity
Pharmacology & pharmacy
Yayın Tarihi: Eyl-2015
Yayıncı: Verduci Publisher
Atıf: Altıntaş, N. vd. (2015). "Neutrophil-to-lymphocyte ratio in obstructive sleep apnea; a multi center, retrospective study". European Review for Medical and Pharmacological Sciences, 19(17), 3234-3240.
Özet: OBJECTIVE: Systemic inflammation is important in pathophysiology of obstructive sleep apnea (OSA) and its comorbidity. Neutrophil to lymphocyte ratio (N/L ratio) is a novel inflammation index that has been shown to independently predict poor clinical outcomes. In this study, we aimed to evaluate the role of N/L ratio in OSA patients and comparing with other well-known inflammatory marker, C-reactive protein (CRP). PATIENTS AND METHODS: We conducted a retrospective analysis of 481 patients with mild, moderate and severe OSA (163,158 and 160 patients, respectively) and leukocyte profiles of 80 sex-, age-and body mass index-matched healthy controls. Patients were excluded if they had underlying cancer, chronic inflammatory disease, any systemic infection, uncontrolled hypertension and diabetes mellitus, a known acute coronary syndrome, valvular heart disease, a known thyroid, renal or hepatic dysfunction. RESULTS: We found that N/L Ratio in severe OSA patients was significantly higher compared with mild, moderate, OSA patients and healthy controls (p < 0.001). However, there was no difference between mild and moderate OSA patients (p = 0.636). There was also no significant difference between mild-moderate OSA patients and healthy groups (p = 0.150). CRP levels were not different in all OSA stages (p = 0.595). By Spearman correlation, there was no correlation between CRP and N/L ratio. CONCLUSIONS: N/L ratio, which is quick, cheap, easily measurable novel inflammatory marker with routine complete blood count analysis, is a surrogate marker of obstructive sleep apnea severity.
URI: http://hdl.handle.net/11452/26903
ISSN: 1128-3602
Koleksiyonlarda Görünür:Scopus
Web of Science

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