Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/27002
Title: In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.
Uludağ Üniversitesi/Fen ve Edebiyat Fakültesi/Biyoloji Bölümü.
Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.
0000-0002-8872-0074
0000-0002-3595-6286
0000-0001-8138-5851
Bağdaş, Deniz
Etöz, Betül Cam
Gül, Zülfiye
Ziyanok, Sedef
İnan, Sevda
Turaçözen, Özge
Gül, Nihal
Topal, Ayşe B.
Çinkılıç, Nilüfer
Taş, Sibel
Özyiğit, Musa Özgür
Gürün, Mine Sibel
AAR-6478-2021
AAF-9939-2020
AAG-8716-2019
E-3364-2018
ABE-6873-2020
AAH-4272-2021
AAH-2873-2021
AAH-5296-2021
15062425700
56427863700
56086542900
9735158200
56320836200
56320248500
8387784600
56357211200
26533892300
7004343411
6507338060
55664349700
Keywords: Chlorogenic acid
Antioxidant
Oxidative stress
Diabetic wound healing
Cytotoxicity
Genotoxicity
Caffeic acid
Oxidative stress
Nitric-oxide
Prooxidant activities
Topical application
Phenethyl ester
Instant coffee
Dna-damage
Rat model
Antioxidant
Food science & technology
Toxicology
Animalia
Rattus
Issue Date: Jul-2015
Publisher: Pergamon-Elsevier Science
Citation: Bağdaş, D. vd. (2015). "In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile". Food and Chemical Toxicology, 81, 54-61.
Abstract: Oxidative stress occurs following the impairment of pro-oxidant/antioxidant balance in chronic wounds and leads to harmful delays in healing progress. A fine balance between oxidative stress and endogenous antioxidant defense system may be beneficial for wound healing under redox control. This study tested the hypothesis that oxidative stress in wound area can be controlled with systemic antioxidant therapy and therefore wound healing can be accelerated. We used chlorogenic acid (CGA), a dietary antioxidant, in experimental diabetic wounds that are characterized by delayed healing. Additionally, we aimed to understand possible side effects of CGA on pivotal organs and bone marrow during therapy. Wounds were created on backs of streptozotocin-induced diabetic rats. CGA (50 mg/kg/day) was injected intraperitoneally. Animals were sacrificed on different days. Biochemical and histopathological examinations were performed. Side effects of chronic antioxidant treatment were tested. CGA accelerated wound healing, enhanced hydroxyproline content, decreased malondialdehyde/nitric oxide levels, elevated reduced-glutathione, and did not affect superoxide dismutase/catalase levels in wound bed. While CGA induced side effects such as cyto/genotoxicity, 15 days of treatment attenuated blood glucose levels. CGA decreased lipid peroxidation levels of main organs. This study provides a better understanding for antioxidant intake on diabetic wound repair and possible pro-oxidative effects.
URI: https://doi.org/10.1016/j.fct.2015.04.001
https://www.sciencedirect.com/science/article/pii/S0278691515001106
http://hdl.handle.net/11452/27002
ISSN: 0278-6915
Appears in Collections:Scopus
Web of Science

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