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Başlık: Management of Brucella endocarditis: Results of the Gulhane study
Yazarlar: Koruk, Suda Tekin
Erdem, Hakan
Koruk, İbrahim
Erbay, Ayşe
Tekce, Yasemin Tezer
Erbay, Ali Rıza
Dayan, Saim
Deveci, Özcan
İnan, Asuman
Engin, Derya Öztürk
Güner, Rahmet
Dikici, Nebahat
Kartal, Elif Doyuk
Kurtaran, Behice
Pehlivanoğlu, Filiz
Sipahi, Oğuz Reşat
Yalcı, Aysun
Yemişen, Mücahit
Çavuş, Sema Alp
Gençer, Serap
Güzel, Gökhan
Öncül, Oral
Parlak, Mehmet
Tülek, Necla
Ulçay, Asım
Savaşçı, Ümit
Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.
Kazak, Esra
AAG-8459-2021
24921238200
Anahtar kelimeler: Infectious diseases
Microbiology
Pharmacology & pharmacy
Brucellosis
Endocarditis
Therapy
Mortality
Infective endocarditis
Bacterial-endocarditis
Risk-factors
Surgery
Aminoglycosides
Diagnosis
Turkey
Adults
Heart
Yayın Tarihi: Ağu-2012
Yayıncı: Elsevier
Atıf: Koruk, S. T. vd. (2012). "Management of Brucella endocarditis: Results of the Gulhane study". International Journal of Antimicrobial Agents, 40(2), 145-150.
Özet: Brucella endocarditis (BE) is a rare but life-threatening complication of human brucellosis. The aim of this study was to investigate the course of BE along with the therapeutic interrelations. A total of 53 patients with BE hospitalised in 19 health institutions between 2006 and 2011 were included in the Gulhane study. Diagnosis of brucellosis was established by either isolation of Brucella sp. or the presence of antibodies, and the definition of endocarditis was made according to Duke's criteria. There were four treatment groups: ceftriaxone combined with oral antibiotics (Group 1); aminoglycosides combined with oral antibiotics (Group 2); oral antibiotic combinations (Group 3); and aminoglycoside plus ceftriaxone combined with an oral antibiotic (Group 4). Involvement rates of the aortic, mitral and tricuspid valves were 49.1%, 43.4% and 5.7%, respectively. Thirty-two patients (60.4%) had an underlying cardiac valvular problem, including previous prosthetic valve replacement (n = 18). Medical treatment was provided to 32 patients (60.4%), whilst concordant medical and surgical approaches were provided to 21 patients (39.6%). Mortality in Group 1 was 15% (3/20), whilst in Group 2 it was 5.3% (1/19). In Group 3, 25.0% (3/12) of the cases died, whereas none of the cases in Group 4 died. In conclusion, mortality increased 47-fold with pericardial effusion and 25-fold due to congestive heart failure that developed after BE. Although mortality was lower in the aminoglycoside-containing arm (Groups 2 and 4), statistical analysis could not be performed owing to the small number of patients.
URI: https://doi.org/10.1016/j.ijantimicag.2012.04.009
https://www.sciencedirect.com/science/article/pii/S0924857912001793
http://hdl.handle.net/11452/27365
ISSN: 0924-8579
Koleksiyonlarda Görünür:Scopus
Web of Science

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