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Başlık: Maspin expression in gastrointestinal stromal tumors
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.
Adım, Şaduman Balaban
Filiz, Gülaydan
Kanat, Özkan
Yerci, Ömer
Özgüç, Halil Bülent
Aytaç, Berna
AAH-9746-2021
15730076300
6602693514
55881548500
6603810549
6603867989
56527372000
Anahtar kelimeler: Paradoxical expression
P53 expression
Gene
Carcinoma
Cancer
Angiogenesis
Progression
Mammary
Serpin
Cells
Oncology
Surgery
Yayın Tarihi: 26-Mar-2010
Yayıncı: BMC
Atıf: Adım, Ş. B. vd. (2010). "Maspin expression in gastrointestinal stromal tumors". World Journal of Surgical Oncology, 8.
Özet: Background: To investigate the role of maspin expression in the progression of gastrointestinal stromal tumors, and its value as a prognostic indicator. Methods: In the study 54 patients with GIST diagnosis were included in Uludag University of Faculty of Medicine, Department of Pathology between 1997-2007. The expression of maspin in 54 cases of gastrointestinal stromal tumor was detected by immunohistochemistry and compared with the clinicopathologic tumor parameters. Results: The positive expression rates for maspin in the GISTs were 66,6% (36 of 54 cases). Maspin overexpression was detected in 9 of 29 high risk tumors (31%) and was significantly higher in very low/low (78.6%) and intermediate-risk tumors (63.6%) than high-risk tumors. Conclusions: Maspin expression might be an important factor in tumor progression and patient prognosis in GIST. In the future, larger series may be studied to examine the prognostic significance of maspin in GISTs and, of course, maspin expression may be studied in different mesenchymal tumors.
URI: https://doi.org/10.1186/1477-7819-8-22
https://wjso.biomedcentral.com/articles/10.1186/1477-7819-8-22
http://hdl.handle.net/11452/27440
ISSN: 1477-7819
Koleksiyonlarda Görünür:Scopus
Web of Science

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