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http://hdl.handle.net/11452/27792
Başlık: | Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. 0000-0002-2593-7196 0000-0002-4946-555X Duman, Uğur Yılmazlar, Aysun Öztürk, Ersin Aker, Sibel Sarandöl, Emre Yılmazlar, Tuncay ABE-1716-2020 H-5770-2018 36971700700 55899579900 35070171400 12795285000 55943324800 6701800362 |
Anahtar kelimeler: | Trinitrobenzene sulfonic acid Colitis Levobupivacaine Budesonide Inflammatory-bowel-disease Ulcerative-colitis Local-anesthetics Lidocaine Ropivacaine Proctitis Therapy Cells Gastroenterology & hepatology |
Yayın Tarihi: | 28-May-2010 |
Yayıncı: | Baishideng Publishing Group |
Atıf: | Duman, U. vd. (2010). "Anti-inflammatory efficiency of levobupivacaine in an experimental colitis model". World Journal of Gastroenterology, 16(20), 2537-2541. |
Özet: | AIM: To investigate the efficiency of levobupivacaine in treating experimentally induced colitis in rats. METHODS: Colitis was induced by trinitrobenzene sulfonic acid and ethanol in 30 rats under general anesthesia, and 10 rats were used as a sham group. Subsequent to induction of colitis, rats were divided into three groups; budesonide group received 0.1 mg/kg budesonide, levobupivacaine group received 10 mg/kg levobupivacaine and saline group received 1 mL saline solution via rectal route for 7 d. In the sham group, only routine rectal catheterization was performed without use of any material. At the end of 7 d, laparotomy and total colectomy were performed for histopathological examination in all rats and blood samples were drawn for measurement of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 following cardiac puncture. Macroscopic and microscopic evaluations of the specimens were performed by a pathologist blinded to group assignment of the rats. RESULTS: Weight loss (P = 0.016) and macroscopic examination scores (P = 0.001) were significantly higher in saline group than others. Histopathological scoring was comparable between all colitis groups (P = 0.350). There was no significant difference in TNF-alpha levels and IL-6 levels (P = 0.150). CONCLUSION: The significant improvement in macroscopic scores suggests that levobupivacaine may have topical anti-inflammatory effects in an experimental colitis model; however, this finding was not supported by microscopic findings. |
URI: | https://doi.org/10.3748/wjg.v16.i20.2537 https://www.wjgnet.com/1007-9327/full/v16/i20/2537.htm http://hdl.handle.net/11452/27792 |
ISSN: | 1007-9327 2219-2840 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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