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Başlık: Oxidative-antioxidative systems and their relation with serum S100B levels in patients with schizophrenia: Effects of short term antipsychotic treatment
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Ruh Sağlığı ve Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
0000-0002-2593-7196
Sarandöl, Aslı
Kirli, Selçuk
Akkaya, Cengiz
Altın, Aysun
Demirci, Meral
Sarandöl, Emre
ABE-1716-2020
14020405100
14019745700
14061855100
17134032300
18534643800
55943324800
Anahtar kelimeler: Antipsychotic
Acid reactıve substances
Oxidative stress
S100 B
Schizophrernia
Zalondialdehyde
Superoxide-dismutase
Lipid peroxides
Fatty-acids
Vitamin-c
Plasma
Stress
Psychosis
Proteins
1st-Episode
Yayın Tarihi: 15-Ağu-2007
Yayıncı: Pergamon-Elsevier Science
Atıf: Sarandöl, A. vd. (2007). "Oxidative-antioxidative systems and their relation with serum S100B levels in patients with schizophrenia: Effects of short term antipsychotic treatment". Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31(6),1164-1169.
Özet: Oxidative stress may be a contributing factor in the etiopathophysiology of schizophrenia, which may be exacerbated by the treatment with antipsychotics with pro-oxidant properties. Increased levels of SIN B are associated with neurodegenerative disorders, including schizophrenia. The aim of the present study was to investigate the role of oxidative cell damage in the pathogenesis of schizophrenia. Forty patients who fully met the fourth Diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia and 35 healthy control subjects were included in the study. Serum S100 B level was determined to investigate brain damage. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cell (RBC) to oxidation were determined to investigate the oxidative status and plasma vitamin E, vitamin C, serum total carotenoid levels and total antioxidant capacity and RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase activities were measured to investigate the antioxidative defence before and after 6 weeks of antipsychotic treatment. Plasma MDA and serum S100 B levels and RBC-SOD activity were significantly higher in the schizophrenia group than those of the control group. Treatment did not modify any of the oxidative-antioxidative system parameters or serum SIN B levels. S100 B level was significantly higher in patients with negative symptoms than the patients with positive symptoms and the control subjects. S100 B levels were significantly reduced after 6 weeks of treatment in patients with negative symptoms. The results of the present study might support the oxidative cell injury hypothesis of the schizophrenia. Furthermore, the underlying mechanisms of the subgroups of schizophrenia might be different as suggested by the increased S 100 B levels and its decrement after treatment in patients with negative symptoms.
URI: https://doi.org/10.1016/j.pnpbp.2007.03.008
https://www.sciencedirect.com/science/article/pii/S0278584607001029
http://hdl.handle.net/11452/28173
ISSN: 02785846
Koleksiyonlarda Görünür:Web of Science

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