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Başlık: Transfusion from male-only versus female donors in critically ill recipients of high plasma, volume components
Yazarlar: Gajic, Ognjen
Yılmaz, Murat
Kor, Darly J.
Winters, J. L.
Moore, S. Breanndan
Afessa, Bekele
Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon/Yoğun Bakım Bilim Dalı.
0000-0001-8111-5958
İşçimen, Remzi
AAI-8104-2021
16645821200
Anahtar kelimeler: Adult
Acute lung injury
Cohort study
Fresh frozen plasma
Outcome
Platelet transfusion
Prevention
Respiratory distress
Consensus conference
Clinical-trial
Outcomes
Care
Yayın Tarihi: Tem-2007
Yayıncı: Lippincott Williams & Wilkins
Atıf: Gajic, O. vd. (2007). "Transfusion from male-only versus female donors in critically ill recipients of high plasma, volume components". Critical Care Medicine, 35(7), 1645-1648.
Özet: Objective: To reduce the incidence of transfusion-related acute lung injury (ALI), the American Association of Blood Banks recently recommended rapid implementation of strategies to minimize transfusion of high plasma volume components, fresh frozen plasma and apheresis platelets, from potentially alloimmunized donors, especially females. The objective of this study was to evaluate the effect of transfusing components from male-only vs. female donors on development of ALI, gas exchange, and outcome in critically ill patients. Design: In this retrospective case-control study, we identified patients who received high plasma volume components from male-only donors and compared them with patients matched by severity of illness, postoperative state, and number of transfusions but who received high plasma volume components from female donors. Setting: Four intensive care units at a tertiary medical center. Patients: Critically ill patients who received > 2 units of fresh frozen plasma or apheresis platelets. Interventions: None. Measurements and Main Results: From a database of 3,567 patients who received a total of 46,101 units of fresh frozen plasma and 6,251 units of apheresis platelets, we identified 112 patients who received three or more male-only donor components and 112 matched controls. Baseline characteristics, ALI risk factors, and development of ALI were similar between the two groups. Arterial oxygenation (Pao(2)/Fio(2)) worsened after the female (mean difference -52, 95% confidence interval -14 to -91, p = .008) but not after male-only donor product transfusion (mean difference 22, 95% confidence interval -23 to 67, p = .325). Male-only component recipients had more ventilator-free days (median 28 vs. 27, p = .006) and a trend toward lower hospital mortality rates (14% vs. 24%, p = .054). Conclusions: In critically ill recipients of high plasma volume components, gas exchange worsened significantly after transfusion of female but not male donor components. Prospective studies are needed to evaluate the effect of recommendations by the American Association of Blood Banks on outcome of transfused critically ill patients.
URI: https://doi.org/10.1097/01.CCM.0000269036.16398.0D
https://journals.lww.com/ccmjournal/Fulltext/2007/07000/Transfusion_from_male_only_versus_female_donors_in.2.aspx
http://hdl.handle.net/11452/28227
ISSN: 0090-3493
1530-0293
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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