Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28260
Title: Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer
Authors: Ayyıldız, Talat
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.
Dolar, Enver
Uğraş, Nesrin
Adım, Şaduman Balaban
Yerci, Ömer
AAG-9177-2021
AAH-2716-2021
6602075084
55386535600
15730076300
6603810549
Keywords: Adiponectin receptor
Adipo-R1/-R2
Colorectal carcinoma
Prognosis
Plasma adiponectin
Colon-cancer
Serum adiponectin
Insulin sensitivity
Tissue expression
Gastric-cancer
Risk
Protein
Obesity
Hypoadiponectinemia
Oncology
Issue Date: 2014
Publisher: Asian Pacific Organization Cancer Prevention
Citation: Ayyıldız, T. vd. (2014). "Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer". Asian Pacific Journal of Cancer Prevention, 15(21), 9385-9390.
Abstract: Introduction: Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensively produced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expression immunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigated effects of adiponectin receptor expression on CRC characteristics. Objectives: In the present study, we aimed to explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathological characteristics and survival. Materials and Methods: The study enrolled 58 colorectal cancer patients with tumor resection and a control group of 30 subjects with normal colon mucosa. Results: Positivity for Adipo-R1/-R2 expression was significantly more common in the control group in comparison to the patient group (both p<0.001). There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristics including age, sex tumor location, pTNM stage, Duke's stage, metastasis, histological differentiation, perineural invasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. AdipoR1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758) and (0.274, 0.232), respectively]. Conclusions: Although significantly reduced Adipo-R1/-R2 expression was found in colorectal cancer patients, it had no influence on survival.
URI: https://doi.org/10.7314/APJCP.2014.15.21.9385
http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25422229&key=2014.15.21.9385
http://hdl.handle.net/11452/28260
ISSN: 1513-7368
Appears in Collections:Scopus
Web of Science

Files in This Item:
File Description SizeFormat 
Dolar_vd_2014.pdf1.04 MBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons