Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28267
Title: Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro
Authors: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
0000-0003-1620-1918
0000-0002-3595-6286
0000-0002-7687-3284
Cinkılıç, Nilüfer
Tüzün, Ece
Çetintaş, Sibel Kahraman
Vatan, Özgür
Yılmaz, Dilek
Çavaş, Tolga
Tunç, Sema
Özkan, Lütfi
Bilaloğlu, Rahmi
AAH-3508-2021
AAH-5296-2021
AAA-7047-2020
O-7508-2015
26533892300
55150260600
6505881756
16235098100
6701369462
6602989548
55557323500
55915679400
6505804122
Keywords: Radioprotection
Cinnamic acid
X-ray radiation
Micronuclei
Alkaline comet assay
Genomic instability
Induced DNA-damage
Gamma-radiation
Lipid-peroxidation
Chromosomal damage
Antioxidants
Derivatives
Assay
Micronuclei
Flavonoids
Generation
Biotechnology & applied microbiology
Genetics & heredity
Toxicology
Issue Date: Aug-2014
Publisher: Elsevier
Citation: Cinkılıç, N. vd. (2014). "Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro". Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 770, 72-79.
Abstract: The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline comet assay, with human blood lymphocytes isolated from two healthy donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for the irradiation with 1 or 2 Gy. Treatment of the lymphocytes with cinnamic acid prior to irradiation reduced the number of micronuclei when compared with that in control samples. Treatment with cinnamic acid without irradiation did not increase the number of micronuclei and did not show a cytostatic effect in the lymphocytes. The results of the alkaline comet assay revealed that cinnamic acid reduces the DNA damage induced by X-rays, showing a significant radio-protective effect. Cinnamic acid decreased the frequency of irradiation-induced micronuclei by 16-55% and reduced DNA breakage by 17-50%, as determined by the alkaline comet assay. Cinnamic acid may thus act as a radio-protective compound, and future studies may focus on elucidating the mechanism by which cinnamic acid offers radioprotection.
URI: https://doi.org/10.1016/j.mrgentox.2014.04.025
https://www.sciencedirect.com/science/article/pii/S1383571814001594
http://hdl.handle.net/11452/28267
ISSN: 1383-5718
1879-3592
Appears in Collections:Scopus
Web of Science

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