Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28272
Title: Association of breast cancer and cytokine gene polymorphism in Turkish women
Authors: Gönüllü, Güzin
Baştürk, Bilkay
Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Immünoloji Anabilim Dalı.
Evrensel, Türkkan
Oral, Barbaros
Gözkaman, Ayşe
Manavoğlu, Osman
6603942124
7004498001
9633205800
6602587152
Keywords: Promoter polymorphism
Growth-factors
Risk
Interleukin-10
Susceptibility
Il-10
Expression
Survival
Issue Date: Nov-2007
Publisher: Saudi Medical Journal
Citation: Gönüllü, G. vd. (2007). "Association of breast cancer and cytokine gene polymorphism in Turkish women". Saudi Medical Journal, 28(11), 1728-1733.
Abstract: Objective: To investigate the association of cytokine gene polymorphism with the development of breast cancer. Methods: The study was carried out in Uludag University Medical School, Bursa, Turkey. The study included 38 patients with breast cancer admitted to the Medical Oncology outpatient clinic, and 24 healthy controls, age and sex matched, from the Internal Medicine Department between 2004 and 2005. All genotyping of tumor necrosis factor-cc (TNF-alpha), tumor growth factor-beta 1 (TGF-beta 1), interleukin (IL)-10, IL-6, and interferon-gamma (IFN-gamma) experiments were performed using polymerase chain reaction sequence-specific primers. Results: The frequencies of IL-6-174GC genotype and IL-10 (-1082, -819, -592) GCC/ATA haplotype were significantly higher in the patient group (p=0.0008) when compared with controls (p=0.020). Significantly lower frequencies of IL-10 (-1082,-819,-592) ACC/ATA haplotype were observed in the patient group in comparison to the controls (p=0.026). The distribution of IFN-gamma +874, TNF-a 308, and TGF-beta 1 codon 10-25 genotypes failed to show any statistical significant association with the development of breast cancer. Conclusion: Our data suggest that IL-10 (-1082, -819, -592) GCC/ATA haplotype and IL-6-174 GC genotype seem to be potential risk factors for the development of breast cancer. The presence of IL-10ACC/ATA haplotype may be protective for the oncogenesis of breast cancer.
URI: https://smj.org.sa/content/28/11/1728
https://smj.org.sa/content/smj/28/11/1728.full.pdf
http://hdl.handle.net/11452/28272
ISSN: 0379-5284
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