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Başlık: IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis
Yazarlar: Baştürk, Bilkay
Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Anabilim Dalı.
0000-0003-0463-6818
0000-0002-4803-8206
0000-0002-3894-1231
Budak, Ferah
Göral, Güher
Heper, Yasemin
Yılmaz, Emel
Aymak, Figen
Töre, Okan
Ener, Beyza
Oral, Haluk B.
AAH-6506-2021
AAG-8523-2021
K-7285-2012
F-4657-2014
A-5841-2017
6701913697
6603453166
56191003300
22037135100
16645073100
6505909596
15053025300
7004498001
Anahtar kelimeler: Brucellosis
Cytokine
Genotyping
IL-10
IL-6
PCR-SSP
Necrosis-factor-alpha
Ifn-gamma productıon
Promoter polymorphism
Online databases
Human-disease
Nitric-oxide
Interferon-gamma
Abortus
Association
Immunty
Yayın Tarihi: Nis-2007
Yayıncı: Academic Press
Atıf: Budak, F. vd. (2007). "IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis". Cytokine, 38(1), 32-36.
Özet: Several genes encoding for different cytokines may play crucial roles in host susceptibility to Brucellosis, since the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphism. The association of the cytokine gene polymorphisms with the development of Brucellosis was investigated in this study. DNA samples were obtained from a Turkish population of 40 patients with Brucellosis, and 50 healthy control subjects. All genotyping (IL-6, IL10, IFN-γ, TGF-β and TNF-α) experiments were performed using sequence-specific primers PCR (PCR-SSP). When compared to the healthy controls, the frequencies of high/intermediate producing genotypes of IL-10 and high producing genotype of IL-6 were significantly more common in the patient group. These results suggest that IL-10 and IL-6 gene polymorphisms may affect susceptibility to Brucellosis and increase risk of developing the disease. In order to confirm the biological significance of our results, further studies should be performed in larger population groups.
URI: https://doi.org/10.1016/j.cyto.2007.04.008
https://www.sciencedirect.com/science/article/pii/S1043466607000877
http://hdl.handle.net/11452/28506
ISSN: 10434666
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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