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Başlık: Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.
0000-0003-3604-8826
0000-0002-2382-290X
0000-0002-9027-1132
Ursavaş, Ahmet
Karadağ, Mehmet
İlçöz, Yasemin
Ercan, İlker
Burgazoğlu, Başak
Coşkun, Funda
Gözü, R. Oktay
AAI-3169-2021
AAG-8744-2021
AAD-1271-2019
AAL-8873-2021
8329319900
6601970351
35741320500
6603789069
15836471100
21734137500
15836640800
Anahtar kelimeler: Insulin-like growth factor
Growth-factor-i
Respiratory system
Obesity
Sleep apnea
Coronary-artery disease
Hormone secretion
Somatomedin-c
Heart-disease
Serum-levels
Body-mass
Insulin
Association
Gender
Yayın Tarihi: Eyl-2007
Yayıncı: Springer
Atıf: Ursavaş, A. vd. (2007). "Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome". Lung, 185(5), 309-314.
Özet: The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.
URI: https://doi.org/10.1007/s00408-007-9026-x
https://link.springer.com/article/10.1007%2Fs00408-007-9026-x
http://hdl.handle.net/11452/28638
ISSN: 0341-2040
1432-1750
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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